Resilience to the short- and long-term behavioral effects of intermittent repeated social defeat in adolescent male mice
Calpe-López, Claudia ; Martínez-Caballero, Maria Ángeles ; García-Pardo, Maria Pilar (Universidad de Zaragoza) ; Aguilar, Maria A.
Resumen: Background
Exposure to intermittent repeated social defeat (IRSD) increases the sensitivity of mice to the rewarding effects of cocaine in the conditioned place preference (CPP) paradigm. Some animals are resilient to this effect of IRSD, though research exploring this inconsistency in adolescent mice is scarce. Thus, our aim was to characterize the behavioral profile of mice exposed to IRSD during early adolescence and to explore a potential association with resilience to the short- and long-term effects of IRSD.
Methods
Thirty-six male C57BL/6 mice were exposed to IRSD during early adolescence (PND 27, 30, 33 and 36), while another 10 male mice did not undergo stress (controls). Defeated mice and controls then carried out the following battery of behavioral tests; the Elevated Plus Maze, Hole-Board and Social Interaction Test on PND 37, and the Tail Suspension and Splash tests on PND 38. Three weeks later, all the mice were submitted to the CPP paradigm with a low dose of cocaine (1.5 mg/kg).
Results
IRSD during early adolescence induced depressive-like behavior in the Social Interaction and Splash tests and increased the rewarding effects of cocaine. Mice with low levels of submissive behavior during episodes of defeat were resilient to the short- and long-term effects of IRSD. In addition, resilience to the short-term effects of IRSD on social interaction and grooming behavior predicted resilience to the long-term effects of IRSD on cocaine reward.
Conclusion
Our findings help to characterize the nature of resilience to the effects of social stress during adolescence.
Idioma: Inglés
DOI: 10.1016/j.pbb.2023.173574
Año: 2023
Publicado en: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 227-228 (2023), 173574 [12 pp.]
ISSN: 0091-3057
Factor impacto JCR: 3.3 (2023)
Categ. JCR: BEHAVIORAL SCIENCES rank: 8 / 55 = 0.145 (2023) - Q1 - T1
Categ. JCR: PHARMACOLOGY & PHARMACY rank: 119 / 354 = 0.336 (2023) - Q2 - T2
Categ. JCR: NEUROSCIENCES rank: 124 / 310 = 0.4 (2023) - Q2 - T2
Factor impacto CITESCORE: 6.4 - Behavioral Neuroscience (Q1) - Pharmacology (Q2) - Toxicology (Q2) - Clinical Biochemistry (Q2) - Biochemistry (Q2) - Biological Psychiatry (Q2)
Factor impacto SCIMAGO: 1.05 - Behavioral Neuroscience (Q1) - Biochemistry (Q1) - Toxicology (Q1) - Clinical Biochemistry (Q1) - Pharmacology (Q1) - Biological Psychiatry (Q2)
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2020-118945RB-I00
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PSI2017-83023
Tipo y forma: Article (Published version)
Área (Departamento): Área Psicolog.Evolut.Educac (Dpto. Psicología y Sociología)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material.
Exportado de SIDERAL (2024-11-22-12:10:37)
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Exposure to intermittent repeated social defeat (IRSD) increases the sensitivity of mice to the rewarding effects of cocaine in the conditioned place preference (CPP) paradigm. Some animals are resilient to this effect of IRSD, though research exploring this inconsistency in adolescent mice is scarce. Thus, our aim was to characterize the behavioral profile of mice exposed to IRSD during early adolescence and to explore a potential association with resilience to the short- and long-term effects of IRSD.
Methods
Thirty-six male C57BL/6 mice were exposed to IRSD during early adolescence (PND 27, 30, 33 and 36), while another 10 male mice did not undergo stress (controls). Defeated mice and controls then carried out the following battery of behavioral tests; the Elevated Plus Maze, Hole-Board and Social Interaction Test on PND 37, and the Tail Suspension and Splash tests on PND 38. Three weeks later, all the mice were submitted to the CPP paradigm with a low dose of cocaine (1.5 mg/kg).
Results
IRSD during early adolescence induced depressive-like behavior in the Social Interaction and Splash tests and increased the rewarding effects of cocaine. Mice with low levels of submissive behavior during episodes of defeat were resilient to the short- and long-term effects of IRSD. In addition, resilience to the short-term effects of IRSD on social interaction and grooming behavior predicted resilience to the long-term effects of IRSD on cocaine reward.
Conclusion
Our findings help to characterize the nature of resilience to the effects of social stress during adolescence.
Idioma: Inglés
DOI: 10.1016/j.pbb.2023.173574
Año: 2023
Publicado en: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 227-228 (2023), 173574 [12 pp.]
ISSN: 0091-3057
Factor impacto JCR: 3.3 (2023)
Categ. JCR: BEHAVIORAL SCIENCES rank: 8 / 55 = 0.145 (2023) - Q1 - T1
Categ. JCR: PHARMACOLOGY & PHARMACY rank: 119 / 354 = 0.336 (2023) - Q2 - T2
Categ. JCR: NEUROSCIENCES rank: 124 / 310 = 0.4 (2023) - Q2 - T2
Factor impacto CITESCORE: 6.4 - Behavioral Neuroscience (Q1) - Pharmacology (Q2) - Toxicology (Q2) - Clinical Biochemistry (Q2) - Biochemistry (Q2) - Biological Psychiatry (Q2)
Factor impacto SCIMAGO: 1.05 - Behavioral Neuroscience (Q1) - Biochemistry (Q1) - Toxicology (Q1) - Clinical Biochemistry (Q1) - Pharmacology (Q1) - Biological Psychiatry (Q2)
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2020-118945RB-I00
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PSI2017-83023
Tipo y forma: Article (Published version)
Área (Departamento): Área Psicolog.Evolut.Educac (Dpto. Psicología y Sociología)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material. Exportado de SIDERAL (2024-11-22-12:10:37)
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Record created 2023-09-21, last modified 2024-11-25