000127753 001__ 127753
000127753 005__ 20241125101127.0
000127753 0247_ $$2doi$$a10.3389/fnut.2023.1227431
000127753 0248_ $$2sideral$$a134961
000127753 037__ $$aART-2023-134961
000127753 041__ $$aeng
000127753 100__ $$aOrtí, Jose Enrique de la Rubia
000127753 245__ $$aExploring the impact of ketogenic diet on multiple sclerosis: obesity, anxiety, depression, and the glutamate system
000127753 260__ $$c2023
000127753 5060_ $$aAccess copy available to the general public$$fUnrestricted
000127753 5203_ $$aMultiple sclerosis (MS) is a neurodegenerative disorder. Individuals with MS frequently present symptoms such as functional disability, obesity, and anxiety and depression. Axonal demyelination can be observed and implies alterations in mitochondrial activity and increased inflammation associated with disruptions in glutamate neurotransmitter activity. In this context, the ketogenic diet (KD), which promotes the production of ketone bodies in the blood [mainly β-hydroxybutyrate (βHB)], is a non-pharmacological therapeutic alternative that has shown promising results in peripheral obesity reduction and central inflammation reduction. However, the association of this type of diet with emotional symptoms through the modulation of glutamate activity in MS individuals remains unknown.AimTo provide an update on the topic and discuss the potential impact of KD on anxiety and depression through the modulation of glutamate activity in subjects with MS.DiscussionThe main findings suggest that the KD, as a source of ketone bodies in the blood, improves glutamate activity by reducing obesity, which is associated with insulin resistance and dyslipidemia, promoting central inflammation (particularly through an increase in interleukins IL-1β, IL-6, and IL-17). This improvement would imply a decrease in extrasynaptic glutamate activity, which has been linked to functional disability and the presence of emotional disorders such as anxiety and depression.
000127753 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000127753 590__ $$a4.0$$b2023
000127753 592__ $$a0.828$$b2023
000127753 591__ $$aNUTRITION & DIETETICS$$b31 / 114 = 0.272$$c2023$$dQ2$$eT1
000127753 593__ $$aFood Science$$c2023$$dQ1
000127753 593__ $$aNutrition and Dietetics$$c2023$$dQ2
000127753 593__ $$aEndocrinology, Diabetes and Metabolism$$c2023$$dQ2
000127753 594__ $$a5.2$$b2023
000127753 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000127753 700__ $$aCuerda-Ballester, María
000127753 700__ $$aSanchis-Sanchis, Claudia Emmanuela
000127753 700__ $$aLajara Romance, Jose María
000127753 700__ $$aNavarro-Illana, Esther
000127753 700__ $$aGarcía Pardo, María Pilar$$uUniversidad de Zaragoza
000127753 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac
000127753 773__ $$g10 (2023), 1227431 [9 pp]$$pFront. Nutr.$$tFrontiers in Nutrition$$x2296-861X
000127753 8564_ $$s1151279$$uhttps://zaguan.unizar.es/record/127753/files/texto_completo.pdf$$yVersión publicada
000127753 8564_ $$s2053150$$uhttps://zaguan.unizar.es/record/127753/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000127753 909CO $$ooai:zaguan.unizar.es:127753$$particulos$$pdriver
000127753 951__ $$a2024-11-22-11:57:53
000127753 980__ $$aARTICLE