Noncytotoxic Roles of Granzymes in Health and Disease

Richardson, Katlyn C. ; Jung, Karen ; Pardo, Julian (Universidad de Zaragoza) ; Turner, Christopher T. ; Granville, David J.

Resumen: Granzymes are serine proteases previously believed to play exclusive and somewhat redundant roles in lymphocyte-mediated target cell death. However, recent studies have challenged this paradigm. Distinct substrate profiles and functions have since emerged for each granzyme while their dysregulated proteolytic activities have been linked to diverse pathologies.

Idioma: Inglés

DOI: 10.1152/physiol.00011.2022

Año: 2022

Publicado en: PHYSIOLOGY 37, 6 (2022), 323-348
ISSN: 1548-9213

Factor impacto JCR: 8.4 (2022)

Categ. JCR: PHYSIOLOGY rank: 5 / 79 = 0.063 (2022) - Q1 - T1

Factor impacto CITESCORE: 17.7 - Biochemistry, Genetics and Molecular Biology (Q1)

Factor impacto SCIMAGO: 2.552 - Physiology (Q1)

Tipo y forma: Review (PostPrint)

Área (Departamento): Área Inmunología (Dpto. Microb.Ped.Radio.Sal.Pú.)