Fiber-Optic-Based System for High-Resolution Monitoring of Stretch in Excised Tissues

Velarte, Antonio (Universidad de Zaragoza) ; Otin, Aranzazu (Universidad de Zaragoza) ; Giménez-Gómez, Pablo ; Muñoz-Berbel, Xavier ; Pueyo, Esther (Universidad de Zaragoza)

Resumen: Cardiovascular diseases cause a high number of deaths nowadays. To improve these statistics, new strategies to better understand the electrical and mechanical abnormalities underlying them are urgently required. This study focuses on the development of a sensor to measure tissue stretch in excised tissues, enabling improved knowledge of biomechanical properties and allowing greater control in real time. A system made of biocompatible materials is described, which is based on two cantilevered platforms that integrate an optical fiber inside them to quantify the amount of stretch the tissues are exposed to with a precision of μm. The operating principle of the sensor is based on the variation of the optical path with the movement of the platforms onto which the samples are fixed. The conducted tests highlight that this system, based on a simple topology and technology, is capable of achieving the desired purpose (a resolution of ∼1 μm), enabling the tissue to be bathed in any medium within the system.

Idioma: Inglés

DOI: 10.3390/bios13100900

Año: 2023

Publicado en: Biosensors 13, 10 (2023), 900 [13 pp.]
ISSN: 2079-6374

Factor impacto JCR: 4.9 (2023)

Categ. JCR: CHEMISTRY, ANALYTICAL rank: 19 / 106 = 0.179 (2023) - Q1 - T1
Categ. JCR: INSTRUMENTS & INSTRUMENTATION rank: 13 / 76 = 0.171 (2023) - Q1 - T1
Categ. JCR: NANOSCIENCE & NANOTECHNOLOGY rank: 50 / 141 = 0.355 (2023) - Q2 - T2

Factor impacto CITESCORE: 6.6 - Instrumentation (Q1) - Engineering (miscellaneous) (Q1) - Analytical Chemistry (Q2) - Clinical Biochemistry (Q2) - Biotechnology (Q2) - Biomedical Engineering (Q2)

Factor impacto SCIMAGO: 0.707 - Instrumentation (Q1) - Biomedical Engineering (Q2) - Medicine (miscellaneous) (Q2) - Clinical Biochemistry (Q2) - Analytical Chemistry (Q2) - Biotechnology (Q2)

Financiación: info:eu-repo/grantAgreement/ES/DGA/LMP94_21
Financiación: info:eu-repo/grantAgreement/ES/DGA/T39-23R
Financiación: info:eu-repo/grantAgreement/EUR/ERC-2014-StG-638284
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2019-105674RB-I00
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2021-127653NB-C21
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2022-140556OB-I00
Financiación: info:eu-repo/grantAgreement/ES/MICINN/RTI2018-100773-B-C31
Financiación: info:eu-repo/grantAgreement/EUR/MICINN/TED2021-130459B-I00

Tipo y forma: Article (Published version)

Área (Departamento): Área Tecnología Electrónica (Dpto. Ingeniería Electrón.Com.)
Área (Departamento): Área Teoría Señal y Comunicac. (Dpto. Ingeniería Electrón.Com.)