Nanoparticles Stokes radius assessment through permeability coefficient determination within a new stratified epithelium on-chip model
Fernández-Carro, E. (Universidad de Zaragoza) ; Salomón-Cambero, R. ; Armero, L. ; Castro-Abril, H. A. ; Ayensa-Jiménez, J. ; Martínez, Miguel A. (Universidad de Zaragoza) ; Ochoa, I. (Universidad de Zaragoza) ; Alcaine, C. (Universidad de Zaragoza) ; García, I. ; Ciriza, J. (Universidad de Zaragoza)
Resumen: Tissue barrier permeability plays a crucial role in determining the selective transport of substances across epithelial tissues, including drugs, cosmetic substances, and chemicals. The ability of these substances to cross through tissue barriers affects their absorption into the bloodstream and ultimately their effectiveness. Therefore, the determination of their permeability on these type of tissue barriers represents a useful tool for pharmaceutical and cosmetic industries as well as for toxicological studies.
In this regard, microfluidic devices and organ-on-chip technologies are becoming more important to generate reliable data. We have designed and performed an alternative new stratified epithelia-on-chip model that allows to correlate the Stokes radius and the diffusion of molecules and/or nanoformulations through the in vitro generated barrier and establish a system suitable for the analysis of diffusion through stratified epithelium. Thus, extrapolating from experimental data we can predict the Stokes radius for unknown fluorescent labelled particles within a molecular size range, such as gold nanoparticles.
Idioma: Inglés
DOI: 10.1080/21691401.2023.2253534
Año: 2023
Publicado en: Artificial Cells Nanomedicine and Biotechnology 51, 1 (2023), 466-475
ISSN: 2169-1401
Factor impacto JCR: 4.5 (2023)
Categ. JCR: BIOTECHNOLOGY & APPLIED MICROBIOLOGY rank: 34 / 174 = 0.195 (2023) - Q1 - T1
Categ. JCR: MATERIALS SCIENCE, BIOMATERIALS rank: 22 / 53 = 0.415 (2023) - Q2 - T2
Categ. JCR: ENGINEERING, BIOMEDICAL rank: 35 / 123 = 0.285 (2023) - Q2 - T1
Factor impacto CITESCORE: 10.9 - Pharmaceutical Science (Q1) - Biomedical Engineering (Q1) - Medicine (miscellaneous) (Q1) - Biotechnology (Q1)
Factor impacto SCIMAGO: 0.646 - Biomedical Engineering (Q2) - Pharmaceutical Science (Q2) - Medicine (miscellaneous) (Q2) - Biotechnology (Q2)
Financiación: info:eu-repo/grantAgreement/ES/DGA/LMP233_21
Tipo y forma: Article (Published version)
Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)
Área (Departamento): Area Histología (Dpto. Anatom.Histolog.Humanas)
Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
Exportado de SIDERAL (2024-11-22-11:57:42)
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In this regard, microfluidic devices and organ-on-chip technologies are becoming more important to generate reliable data. We have designed and performed an alternative new stratified epithelia-on-chip model that allows to correlate the Stokes radius and the diffusion of molecules and/or nanoformulations through the in vitro generated barrier and establish a system suitable for the analysis of diffusion through stratified epithelium. Thus, extrapolating from experimental data we can predict the Stokes radius for unknown fluorescent labelled particles within a molecular size range, such as gold nanoparticles.
Idioma: Inglés
DOI: 10.1080/21691401.2023.2253534
Año: 2023
Publicado en: Artificial Cells Nanomedicine and Biotechnology 51, 1 (2023), 466-475
ISSN: 2169-1401
Factor impacto JCR: 4.5 (2023)
Categ. JCR: BIOTECHNOLOGY & APPLIED MICROBIOLOGY rank: 34 / 174 = 0.195 (2023) - Q1 - T1
Categ. JCR: MATERIALS SCIENCE, BIOMATERIALS rank: 22 / 53 = 0.415 (2023) - Q2 - T2
Categ. JCR: ENGINEERING, BIOMEDICAL rank: 35 / 123 = 0.285 (2023) - Q2 - T1
Factor impacto CITESCORE: 10.9 - Pharmaceutical Science (Q1) - Biomedical Engineering (Q1) - Medicine (miscellaneous) (Q1) - Biotechnology (Q1)
Factor impacto SCIMAGO: 0.646 - Biomedical Engineering (Q2) - Pharmaceutical Science (Q2) - Medicine (miscellaneous) (Q2) - Biotechnology (Q2)
Financiación: info:eu-repo/grantAgreement/ES/DGA/LMP233_21
Tipo y forma: Article (Published version)
Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)
Área (Departamento): Area Histología (Dpto. Anatom.Histolog.Humanas)
Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2024-11-22-11:57:42)
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Este artículo se encuentra en las siguientes colecciones:
Articles > Artículos por área > Mec. de Medios Contínuos y Teor. de Estructuras
Articles > Artículos por área > Enfermería
Articles > Artículos por área > Histología
Record created 2023-10-27, last modified 2024-11-25