000128008 001__ 128008
000128008 005__ 20241125101126.0
000128008 0247_ $$2doi$$a10.1080/21691401.2023.2253534
000128008 0248_ $$2sideral$$a135181
000128008 037__ $$aART-2023-135181
000128008 041__ $$aeng
000128008 100__ $$aFernández-Carro, E.$$uUniversidad de Zaragoza
000128008 245__ $$aNanoparticles Stokes radius assessment through permeability coefficient determination within a new stratified epithelium on-chip model
000128008 260__ $$c2023
000128008 5060_ $$aAccess copy available to the general public$$fUnrestricted
000128008 5203_ $$aTissue barrier permeability plays a crucial role in determining the selective transport of substances across epithelial tissues, including drugs, cosmetic substances, and chemicals. The ability of these substances to cross through tissue barriers affects their absorption into the bloodstream and ultimately their effectiveness. Therefore, the determination of their permeability on these type of tissue barriers represents a useful tool for pharmaceutical and cosmetic industries as well as for toxicological studies.
In this regard, microfluidic devices and organ-on-chip technologies are becoming more important to generate reliable data. We have designed and performed an alternative new stratified epithelia-on-chip model that allows to correlate the Stokes radius and the diffusion of molecules and/or nanoformulations through the in vitro generated barrier and establish a system suitable for the analysis of diffusion through stratified epithelium. Thus, extrapolating from experimental data we can predict the Stokes radius for unknown fluorescent labelled particles within a molecular size range, such as gold nanoparticles.
000128008 536__ $$9info:eu-repo/grantAgreement/ES/DGA/LMP233_21
000128008 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000128008 590__ $$a4.5$$b2023
000128008 592__ $$a0.646$$b2023
000128008 591__ $$aBIOTECHNOLOGY & APPLIED MICROBIOLOGY$$b34 / 174 = 0.195$$c2023$$dQ1$$eT1
000128008 593__ $$aBiomedical Engineering$$c2023$$dQ2
000128008 591__ $$aMATERIALS SCIENCE, BIOMATERIALS$$b22 / 53 = 0.415$$c2023$$dQ2$$eT2
000128008 593__ $$aPharmaceutical Science$$c2023$$dQ2
000128008 591__ $$aENGINEERING, BIOMEDICAL$$b35 / 123 = 0.285$$c2023$$dQ2$$eT1
000128008 593__ $$aMedicine (miscellaneous)$$c2023$$dQ2
000128008 593__ $$aBiotechnology$$c2023$$dQ2
000128008 594__ $$a10.9$$b2023
000128008 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000128008 700__ $$aSalomón-Cambero, R.
000128008 700__ $$aArmero, L.
000128008 700__ $$aCastro-Abril, H. A.
000128008 700__ $$0(orcid)0000-0003-2564-6038$$aAyensa-Jiménez, J.
000128008 700__ $$0(orcid)0000-0002-8375-0354$$aMartínez, Miguel A.$$uUniversidad de Zaragoza
000128008 700__ $$0(orcid)0000-0003-2410-5678$$aOchoa, I.$$uUniversidad de Zaragoza
000128008 700__ $$0(orcid)0000-0002-7854-8856$$aAlcaine, C.$$uUniversidad de Zaragoza
000128008 700__ $$aGarcía, I.
000128008 700__ $$0(orcid)0000-0002-8666-622X$$aCiriza, J.$$uUniversidad de Zaragoza
000128008 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000128008 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000128008 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000128008 773__ $$g51, 1 (2023), 466-475$$tArtificial Cells Nanomedicine and Biotechnology$$x2169-1401
000128008 8564_ $$s2649570$$uhttps://zaguan.unizar.es/record/128008/files/texto_completo.pdf$$yVersión publicada
000128008 8564_ $$s1276702$$uhttps://zaguan.unizar.es/record/128008/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000128008 909CO $$ooai:zaguan.unizar.es:128008$$particulos$$pdriver
000128008 951__ $$a2024-11-22-11:57:42
000128008 980__ $$aARTICLE