Fluid flow to mimic organ function in 3D in vitro models

Juste-Lanas, Yago (Universidad de Zaragoza) ; Hervás-Raluy, Silvia (Universidad de Zaragoza) ; García-Aznar, José Manuel (Universidad de Zaragoza) ; González-Loyola, Alejandra (Universidad de Zaragoza)

Resumen: Many different strategies can be found in the literature to model organ physiology, tissue functionality, and disease in vitro; however, most of these models lack the physiological fluid dynamics present in vivo. Here, we highlight the importance of fluid flow for tissue homeostasis, specifically in vessels, other lumen structures, and interstitium, to point out the need of perfusion in current 3D in vitro models. Importantly, the advantages and limitations of the different current experimental fluid-flow setups are discussed. Finally, we shed light on current challenges and future focus of fluid flow models applied to the newest bioengineering state-of-the-art platforms, such as organoids and organ-on-a-chip, as the most sophisticated and physiological preclinical platforms.

Idioma: Inglés

DOI: 10.1063/5.0146000

Año: 2023

Publicado en: APL Bioengineering 7, 3 (2023), 031501 [24 pp.]
ISSN: 2473-2877

Factor impacto SCIMAGO: 1.119 - Bioengineering (Q1) - Biophysics (Q1) - Biomedical Engineering (Q1) - Biomaterials (Q1)

Financiación: info:eu-repo/grantAgreement/EC/H2020/742684/EU/Catalytic Dual-Function Devices Against Cancer/CADENCE
Financiación: info:eu-repo/grantAgreement/ES/MCIU/FPU17-03867
Financiación: info:eu-repo/grantAgreement/ES/MICINN-AEI-FEDER/PID2021-122409OB-C21
Financiación: info:eu-repo/grantAgreement/ES/NextGenerationEU/MZ-240621

Tipo y forma: Article (Published version)

Área (Departamento): Área Biología Celular (Dpto. Bioq.Biolog.Mol. Celular)
Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)