Non-controlled, open-label trial to assess clinical and immunological parameters in atopic dogs feeding monoprotein grain free diet versus a standard grain diet
Verde, María Teresa (Universidad de Zaragoza) ; Villanueva-Saz, Sergio (Universidad de Zaragoza) ; Navarro, Laura (Universidad de Zaragoza) ; Loste, Araceli (Universidad de Zaragoza) ; Marteles, Diana (Universidad de Zaragoza) ; Fernández, Antonio (Universidad de Zaragoza) ; Pereboom, Desirée (Universidad de Zaragoza)
Resumen: Canine atopic dermatitis (cAD) is a common inflammatory skin disease that is treated with medicines or allergen-specific immunotherapy. An improvement diet can help treatment of cAD. The purpose of this study was compare two diets on clinical and immunological parameters in atopic dogs without food hypersensitivity. Diet A, a commercial based on rice, was offered to 22 atopic dogs during 30 days and Diet B (grain free, rich in salmon) was given to 8 atopic dogs. Clinical scores were assessed by CADESI-4 and PVAS at the beginning (T0) and at the end of the study (T30). CD4+ and CD8+ were measured in PBMCs, and serum cytokines (TNF-α, IL-10, IL-31 and IL-34) were determined. Both diets decreased CADESI-4 score and Diet A decreased PVAS score (p < 0.05). There were no statistical significant differences between diets at T30 for CD4+ and CD8+. A decrease in the IL-31 concentrations and increase in IL-10 levels (p < 0.05) was observed with Diet A at T30. There were no differences between any of the two diets when the other results at T0 and T30 were compared for any of the parameters analysed. In conclusion, the results indicate that dietary intervention had not influence on cellular component of the immune system, but a positive effect was observed on IL-31, IL-10 serum levels for Diet A. Further studies are needed to enrich dietary components of the food for atopic dogs without food hypersensibility to help improvement the management of the cAD.
Idioma: Inglés
DOI: 10.1080/01652176.2023.2243309
Año: 2023
Publicado en: VETERINARY QUARTERLY 43, 1 (2023), 7
ISSN: 0165-2176
Factor impacto JCR: 7.9 (2023)
Categ. JCR: VETERINARY SCIENCES rank: 2 / 167 = 0.012 (2023) - Q1 - T1
Factor impacto CITESCORE: 13.1 - Veterinary (all) (Q1)
Factor impacto SCIMAGO: 1.26 - Veterinary (miscellaneous) (Q1) - Medicine (miscellaneous) (Q1)
Tipo y forma: Article (Published version)
Área (Departamento): Área Fisiología (Dpto. Farmac.Fisiol.y Med.L.F.)
Área (Departamento): Área Medicina y Cirugía Animal (Dpto. Patología Animal)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
Exportado de SIDERAL (2025-01-24-21:14:53)
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Idioma: Inglés
DOI: 10.1080/01652176.2023.2243309
Año: 2023
Publicado en: VETERINARY QUARTERLY 43, 1 (2023), 7
ISSN: 0165-2176
Factor impacto JCR: 7.9 (2023)
Categ. JCR: VETERINARY SCIENCES rank: 2 / 167 = 0.012 (2023) - Q1 - T1
Factor impacto CITESCORE: 13.1 - Veterinary (all) (Q1)
Factor impacto SCIMAGO: 1.26 - Veterinary (miscellaneous) (Q1) - Medicine (miscellaneous) (Q1)
Tipo y forma: Article (Published version)
Área (Departamento): Área Fisiología (Dpto. Farmac.Fisiol.y Med.L.F.)
Área (Departamento): Área Medicina y Cirugía Animal (Dpto. Patología Animal)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2025-01-24-21:14:53)
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Record created 2023-10-27, last modified 2025-01-24