Brain tissue mechanics is governed by microscale relations of the tissue constituents

Sáez, P. ; Borau, C. (Universidad de Zaragoza) ; Antonovaite, N. ; Franze, K.

Resumen: Local mechanical tissue properties are a critical regulator of cell function in the central nervous system (CNS) during development and disorder. However, we still don't fully understand how the mechanical properties of individual tissue constituents, such as cell nuclei or myelin, determine tissue mechanics. Here we developed a model predicting local tissue mechanics, which induces non-affine deformations of the tissue components. Using the mouse hippocampus and cerebellum as model systems, we show that considering individual tissue components alone, as identified by immunohistochemistry, is not sufficient to reproduce the local mechanical properties of CNS tissue. Our results suggest that brain tissue shows a universal response to applied forces that depends not only on the amount and stiffness of the individual tissue constituents but also on the way how they assemble. Our model may unify current incongruences between the mechanics of soft biological tissues and the underlying constituents and facilitate the design of better biomedical materials and engineered tissues. To this end, we provide a freely-available platform to predict local tissue elasticity upon providing immunohistochemistry images and stiffness values for the constituents of the tissue.

Idioma: Inglés

DOI: 10.1016/j.biomaterials.2023.122273

Año: 2023

Publicado en: Biomaterials 301 (2023), 122273 [9 pp.]
ISSN: 0142-9612

Factor impacto JCR: 12.8 (2023)

Categ. JCR: MATERIALS SCIENCE, BIOMATERIALS rank: 2 / 53 = 0.038 (2023) - Q1 - T1
Categ. JCR: ENGINEERING, BIOMEDICAL rank: 4 / 123 = 0.033 (2023) - Q1 - T1

Factor impacto CITESCORE: 26.0 - Biophysics (Q1) - Bioengineering (Q1) - Mechanics of Materials (Q1) - Biomaterials (Q1) - Ceramics and Composites (Q1)

Factor impacto SCIMAGO: 3.016 - Bioengineering (Q1) - Biomaterials (Q1) - Nanoscience and Nanotechnology (Q1) - Ceramics and Composites (Q1) - Mechanics of Materials (Q1) - Biophysics (Q1)

Financiación: info:eu-repo/grantAgreement/EC/FP7/615170/EU/MICROMACHINED OPTOMECHANICAL DEVICES: looking at cells, tissues, and organs ... with a gentle touch/DIDYMUS
Financiación: info:eu-repo/grantAgreement/EC/H2020/772426/EU/The integration of mechanical and chemical signals in neuronal guidance/MECHEMGUI

Tipo y forma: Article (Published version)

Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)