Evaluation of Cytocompatibility of PEEK-Based Composites as a Function of Manufacturing Processes

Gil-Albarova, Jorge (Universidad de Zaragoza) ; Martínez-Morlanes, María José ; Fernández, José Miguel ; Castell, Pere ; Gracia, Luis ; Puértolas, José Antonio (Universidad de Zaragoza)

Resumen: The biocompatible polymer polyetheretherketone (PEEK) is a suitable candidate to be part of potential all-polymer total joint replacements, provided its use is associated with better osseointegration, mechanical performance, and wear resistance. Seeking to meet the aforementioned requirements, respectively, we have manufactured a PEEK composite with different fillers: carbon fibers (CF), hydroxyapatite particles (HA) and graphene platelets (GNP). The mechanical outcomes of the composites with combinations of 0, 1.5, 3.0 wt% GNP, 5 and 15 wt% HA and 30% of wt% CF concentrations pointed out that one of the best filler combinations to achieve the previous objectives was 30 wt% CF, 8 wt% HA and 2 wt% of GNP. The study compares the bioactivity of human osteoblasts on this composite prepared by injection molding with that on the material manufactured by the Fused Filament Fabrication 3D additive technique. The results indicate that the surface adhesion and proliferation of human osteoblasts over time are better with the composite obtained by injection molding than that obtained by 3D printing. This result is more closely correlated with morphological parameters of the composite surface than its wettability behavior.

Idioma: Inglés

DOI: 10.3390/bioengineering10111327

Año: 2023

Publicado en: Bioengineering 10, 11 (2023), 1327
ISSN: 2306-5354

Factor impacto JCR: 3.8 (2023)

Categ. JCR: ENGINEERING, BIOMEDICAL rank: 44 / 123 = 0.358 (2023) - Q2 - T2

Factor impacto CITESCORE: 4.0 - Bioengineering (Q3)

Factor impacto SCIMAGO: 0.627 - Bioengineering (Q3)

Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/RIS3-LMP21-18
Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/T48-17R

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Traumatología y Ortopedia (Dpto. Cirugía)
Área (Departamento): Área Cienc.Mater. Ingen.Metal. (Dpto. Ciencia Tecnol.Mater.Fl.)