000128215 001__ 128215 000128215 005__ 20250908131405.0 000128215 0247_ $$2doi$$a10.1016/j.jcpa.2023.07.002 000128215 0248_ $$2sideral$$a135526 000128215 037__ $$aART-2023-135526 000128215 041__ $$aeng 000128215 100__ $$0(orcid)0000-0002-9723-9004$$aGómez, Álex$$uUniversidad de Zaragoza 000128215 245__ $$aA case of canine intestinal malakoplakia 000128215 260__ $$c2023 000128215 5060_ $$aAccess copy available to the general public$$fUnrestricted 000128215 5203_ $$aMalakoplakia is a rare chronic granulomatous disease usually affecting the urinary bladder and other locations. In humans, the gastrointestinal tract is the second most common location but there are no reports of intestinal malakoplakia in animals. A 10-month-old female French Bulldog was presented with chronic haemorrhagic diarrhoea and anorexia with normochromic-normocytic anaemia and hypoalbuminaemia. Grossly, there was mucosal thickening and ulceration of the caecum, colon and rectum. Microscopically, transmural sheets of foamy macrophages were seen in these tissues. Macrophages were periodic acid–Schiff, vimentin and ionized calcium-binding adaptor molecule 1 positive and contained von Kossa- and Prussian blue-positive Michaelis–Gutmann bodies. Giemsa staining revealed rod-shaped bacterial colonies and fluorescence in-situ hybridization demonstrated Escherichia coli within macrophages. This is the first reported case of intestinal malakoplakia in domestic animals. Pathological features of intestinal malakoplakia share many similarities with ulcerative histiocytic colitis in dogs but it is unclear if they are different forms of the same pathological process or distinct entities. 000128215 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000128215 590__ $$a0.8$$b2023 000128215 592__ $$a0.376$$b2023 000128215 591__ $$aVETERINARY SCIENCES$$b108 / 167 = 0.647$$c2023$$dQ3$$eT2 000128215 593__ $$aVeterinary (miscellaneous)$$c2023$$dQ2 000128215 591__ $$aPATHOLOGY$$b75 / 88 = 0.852$$c2023$$dQ4$$eT3 000128215 593__ $$aPathology and Forensic Medicine$$c2023$$dQ3 000128215 594__ $$a1.6$$b2023 000128215 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000128215 700__ $$aPérez, Estela$$uUniversidad de Zaragoza 000128215 700__ $$aCalvo-Sánchez, Natalia$$uUniversidad de Zaragoza 000128215 700__ $$0(orcid)0000-0002-8133-2124$$aPérez, Marta$$uUniversidad de Zaragoza 000128215 700__ $$0(orcid)0000-0003-4417-7919$$aBorobia, María 000128215 700__ $$0(orcid)0000-0002-2053-9842$$aLuján, Lluís$$uUniversidad de Zaragoza 000128215 700__ $$0(orcid)0000-0002-2685-1730$$aRodríguez-Largo, Ana$$uUniversidad de Zaragoza 000128215 700__ $$0(orcid)0000-0001-6209-4282$$aVillanueva-Saz, Sergio$$uUniversidad de Zaragoza 000128215 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal 000128215 7102_ $$11001$$2025$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Anatom.Anatom.Patológ.Com 000128215 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal 000128215 773__ $$g205 (2023), 33-37$$pJ. Comp. Pathol.$$tJOURNAL OF COMPARATIVE PATHOLOGY$$x0021-9975 000128215 8564_ $$s3921057$$uhttps://zaguan.unizar.es/record/128215/files/texto_completo.pdf$$yVersión publicada 000128215 8564_ $$s2870522$$uhttps://zaguan.unizar.es/record/128215/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000128215 909CO $$ooai:zaguan.unizar.es:128215$$particulos$$pdriver 000128215 951__ $$a2025-09-08-12:49:21 000128215 980__ $$aARTICLE