Practical considerations for clinical use of mesenchymal stem cells: From the laboratory to the horse

Barrachina, L. (Universidad de Zaragoza) ; Romero, A. (Universidad de Zaragoza) ; Zaragoza, P. (Universidad de Zaragoza) ; Rodellar, C. (Universidad de Zaragoza) ; Vázquez, F.J. (Universidad de Zaragoza)

Resumen: Since the clinical use of mesenchymal stem cells (MSCs) for treating musculoskeletal injuries is gaining popularity, practitioners should be aware of the factors that may affect MSCs from tissue harvesting for MSC isolation to cell delivery into the injury site. This review provides equine practitioners with up-to-date, practical knowledge for the treatment of equine patients using MSCs. A brief overview of laboratory procedures affecting MSCs is provided, but the main focus is on shipping conditions, routes of administration, injection methods, and which commonly used products can be combined with MSCs and which products should be avoided as they have deleterious effects on cells. There are still several knowledge gaps regarding MSC-based therapies in horses. Therefore, it is important to properly manage the factors which are currently known to affect MSCs, to further strengthen the evidence basis of this treatment.

Idioma: Inglés

DOI: 10.1016/j.tvjl.2018.07.004

Año: 2018

Publicado en: Veterinary Journal 238 (2018), 49-57
ISSN: 1090-0233

Factor impacto JCR: 1.919 (2018)

Categ. JCR: VETERINARY SCIENCES rank: 25 / 141 = 0.177 (2018) - Q1 - T1

Factor impacto SCIMAGO: 0.908 - Veterinary (miscellaneous) (Q1) - Animal Science and Zoology (Q1)

Financiación: info:eu-repo/grantAgreement/ES/MICINN/AGL2011-28609
Financiación: info:eu-repo/grantAgreement/ES/MINECO/AGL2008-02428

Tipo y forma: Review (PostPrint)

Área (Departamento): Área Genética (Dpto. Anatom.,Embri.Genét.Ani.)
Área (Departamento): Área Medicina y Cirugía Animal (Dpto. Patología Animal)