Low plasma iron levels associated to drug treatment in polymedicated patients: a case-control study

Lozano, Roberto ; Frutos, Alberto (Universidad de Zaragoza) ; Apesteguía, Alberto ; Martinez, Alejandro ; Franco, María Esther (Universidad de Zaragoza) ; Alcazar, María Ángeles

Resumen: Aim: To identify the drug class and/or duration of treatments causing hyposideremia.

Study Design: Retrospective case-control study.

Place and Duration of Study: Departments of Internal Medicine and Pharmacy, Aragón Health Services Services Hospital Real de Nuestra Señora de Gracia, between January 2019 and December 2019.

Methodology: The records of prescripted medicines of all patients admitted to Internal Medicine service, for various indications, along a 1-year period (2019), which were ultimately analized according to association with hyposideremia.

Results: It was identified several drugs associated with low plasma iron levels: acetylcysteine and apixaban, which would increase the risk of hyposideremia. On the contrary, we found that allopurinol, duloxetine and simvastatin would protect against the appearance of hyposideremia.

Conclusion: Acetylcysteine and apixaban, alone or in combination with different pathologies, would be capable of inducing, and on dependence of the duration of treatment and/or of the concomitant pathology, hyposideremia, iron deficiency and, in certain cases, anemia constituting a major health problem.

Idioma: Inglés

DOI: 10.9734/JAMPS/2020/v22i1030197

Año: 2020

Publicado en: Journal of advances in medical and pharmaceutical sciences 22, 10 (2020), 23-28
ISSN: 2394-1111

Tipo y forma: Article (Published version)

Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Área Medic.Prevent.Salud Públ. (Dpto. Microb.Ped.Radio.Sal.Pú.)