Use of a local anaesthetic/antiseptic formulation for the treatment of lambs experimentally infected with orf virus

Lacasta, Delia (Universidad de Zaragoza) ; Ríos, Marina ; Ruiz de Arcaute, Marta (Universidad de Zaragoza) ; Ortín, Aurora (Universidad de Zaragoza) ; Ramos, Juan José (Universidad de Zaragoza) ; Villanueva-Saz, Sergio (Universidad de Zaragoza) ; Tejedor, María Teresa (Universidad de Zaragoza) ; Ruiz, Héctor (Universidad de Zaragoza) ; Borobia, Marta (Universidad de Zaragoza) ; Reina, Ramsés ; Gómez, Alex (Universidad de Zaragoza) ; Navarro, Teresa (Universidad de Zaragoza) ; Windsor, Peter Andrew

Resumen: Contagious ecthyma is a highly transmissible eruptive viral disease of the skin and mucosa of sheep and goats distributed worldwide. The treatment of orf lesions is usually based on the use of antiseptics and antibiotics for the management of presumptive secondary infections, increasing risks of antimicrobial resistance. The wound dressing formulation Tri-Solfen® (TS) containing two local anaesthetics (lignocaine and bupivacaine), adrenaline and an antiseptic (cetrimide) in a gel formulation has been demonstrated to reduce suffering and enhance recovery in cattle and buffalo with oral and skin lesions due to foot-and-mouth disease virus infection and reduced the orf viral load in lambs. In the present study, experimental infection with the orf virus was conducted in 50 newborn lambs and 25 animals were treated after the presence of the first lesions with TS and repeated three days later. Daily clinical examination, haematological, serological, biomolecular and post-mortem analyses were conducted during 34 days after treatment. Results indicated that treatment had no effect on weight gain and clinical progression of the lesions. It was determined that seroconversion after experimental infection occurs 34 days after infection and suggested that the deep basal epithelial location of the orf lesions may have prevented the therapy from having altered the clinical course.

Idioma: Inglés

DOI: 10.3390/ani13182962

Año: 2023

Publicado en: Animals 13, 18 (2023), 2962 [14 pp.]
ISSN: 2076-2615

Factor impacto JCR: 2.7 (2023)

Categ. JCR: VETERINARY SCIENCES rank: 16 / 167 = 0.096 (2023) - Q1 - T1
Categ. JCR: AGRICULTURE, DAIRY & ANIMAL SCIENCE rank: 10 / 80 = 0.125 (2023) - Q1 - T1

Factor impacto CITESCORE: 4.9 - Animal Science and Zoology (Q1) - Veterinary (all) (Q1)

Factor impacto SCIMAGO: 0.698 - Veterinary (miscellaneous) (Q1) - Animal Science and Zoology (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/Construyendo Aragón 2016–2020-A15-17R

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Genética (Dpto. Anatom.,Embri.Genét.Ani.)
Área (Departamento): Área Sanidad Animal (Dpto. Patología Animal)
Área (Departamento): Área Medicina y Cirugía Animal (Dpto. Patología Animal)