000129415 001__ 129415
000129415 005__ 20250908131417.0
000129415 0247_ $$2doi$$a10.3390/ani13182962
000129415 0248_ $$2sideral$$a135541
000129415 037__ $$aART-2023-135541
000129415 041__ $$aeng
000129415 100__ $$0(orcid)0000-0002-7822-6646$$aLacasta, Delia$$uUniversidad de Zaragoza
000129415 245__ $$aUse of a local anaesthetic/antiseptic formulation for the treatment of lambs experimentally infected with orf virus
000129415 260__ $$c2023
000129415 5060_ $$aAccess copy available to the general public$$fUnrestricted
000129415 5203_ $$aContagious ecthyma is a highly transmissible eruptive viral disease of the skin and mucosa of sheep and goats distributed worldwide. The treatment of orf lesions is usually based on the use of antiseptics and antibiotics for the management of presumptive secondary infections, increasing risks of antimicrobial resistance. The wound dressing formulation Tri-Solfen® (TS) containing two local anaesthetics (lignocaine and bupivacaine), adrenaline and an antiseptic (cetrimide) in a gel formulation has been demonstrated to reduce suffering and enhance recovery in cattle and buffalo with oral and skin lesions due to foot-and-mouth disease virus infection and reduced the orf viral load in lambs. In the present study, experimental infection with the orf virus was conducted in 50 newborn lambs and 25 animals were treated after the presence of the first lesions with TS and repeated three days later. Daily clinical examination, haematological, serological, biomolecular and post-mortem analyses were conducted during 34 days after treatment. Results indicated that treatment had no effect on weight gain and clinical progression of the lesions. It was determined that seroconversion after experimental infection occurs 34 days after infection and suggested that the deep basal epithelial location of the orf lesions may have prevented the therapy from having altered the clinical course.
000129415 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/Construyendo Aragón 2016–2020-A15-17R
000129415 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000129415 590__ $$a2.7$$b2023
000129415 592__ $$a0.698$$b2023
000129415 591__ $$aVETERINARY SCIENCES$$b16 / 167 = 0.096$$c2023$$dQ1$$eT1
000129415 593__ $$aVeterinary (miscellaneous)$$c2023$$dQ1
000129415 591__ $$aAGRICULTURE, DAIRY & ANIMAL SCIENCE$$b10 / 80 = 0.125$$c2023$$dQ1$$eT1
000129415 593__ $$aAnimal Science and Zoology$$c2023$$dQ1
000129415 594__ $$a4.9$$b2023
000129415 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000129415 700__ $$aRíos, Marina
000129415 700__ $$0(orcid)0000-0002-7655-2472$$aRuiz de Arcaute, Marta$$uUniversidad de Zaragoza
000129415 700__ $$0(orcid)0000-0002-0313-5926$$aOrtín, Aurora$$uUniversidad de Zaragoza
000129415 700__ $$0(orcid)0000-0002-2724-2785$$aRamos, Juan José$$uUniversidad de Zaragoza
000129415 700__ $$0(orcid)0000-0001-6209-4282$$aVillanueva-Saz, Sergio$$uUniversidad de Zaragoza
000129415 700__ $$0(orcid)0000-0001-5026-5144$$aTejedor, María Teresa$$uUniversidad de Zaragoza
000129415 700__ $$0(orcid)0000-0002-8474-2831$$aRuiz, Héctor$$uUniversidad de Zaragoza
000129415 700__ $$0(orcid)0000-0002-0680-9957$$aBorobia, Marta$$uUniversidad de Zaragoza
000129415 700__ $$aReina, Ramsés
000129415 700__ $$0(orcid)0000-0002-9723-9004$$aGómez, Alex$$uUniversidad de Zaragoza
000129415 700__ $$0(orcid)0000-0002-4557-6033$$aNavarro, Teresa$$uUniversidad de Zaragoza
000129415 700__ $$aWindsor, Peter Andrew
000129415 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000129415 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000129415 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000129415 773__ $$g13, 18 (2023), 2962 [14 pp.]$$pAnimals (Basel)$$tAnimals$$x2076-2615
000129415 8564_ $$s984563$$uhttps://zaguan.unizar.es/record/129415/files/texto_completo.pdf$$yVersión publicada
000129415 8564_ $$s2926741$$uhttps://zaguan.unizar.es/record/129415/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000129415 909CO $$ooai:zaguan.unizar.es:129415$$particulos$$pdriver
000129415 951__ $$a2025-09-08-12:52:09
000129415 980__ $$aARTICLE