000129524 001__ 129524 000129524 005__ 20240731103420.0 000129524 0247_ $$2doi$$a10.3390/opt4040043 000129524 0248_ $$2sideral$$a135807 000129524 037__ $$aART-2023-135807 000129524 041__ $$aeng 000129524 100__ $$0(orcid)0000-0002-9068-7728$$aÁvila, Francisco J.$$uUniversidad de Zaragoza 000129524 245__ $$aIn vivo biomechanical response of the human cornea to acoustic waves 000129524 260__ $$c2023 000129524 5060_ $$aAccess copy available to the general public$$fUnrestricted 000129524 5203_ $$aThe cornea is the optical window to the brain. Its optical and structural properties are responsible for optical transparency and vision. The shape, elasticity, rigidity, or stiffness are due to its biomechanical properties, whose stability results in ocular integrity and intraocular pressure dynamics. Here, we report in vivo observations of shape changes and biomechanical alterations in the human cornea induced by acoustic wave pressure within the frequency range of 50–350 Hz and the sound pressure level of 90 dB. The central corneal thickness (CCT) and eccentricity (e2) were measured using Scheimpflug imaging and biomechanical properties [corneal hysteresis (CH) and intraocular pressure (IOP)] were assessed with air-puff tonometry in six young, healthy volunteers. At the specific 150 Hz acoustic frequency, the variations in e2 and CCT were 0.058 and 7.33 µm, respectively. Biomechanical alterations were also observed in both the IOP (a decrease of 3.60 mmHg) and CH (an increase of 0.40 mmHg). 000129524 536__ $$9info:eu-repo/grantAgreement/ES/UZ/JIUZ-2021-CIE-01 000129524 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000129524 592__ $$a0.196$$b2023 000129524 593__ $$aAtomic and Molecular Physics, and Optics$$c2023$$dQ4 000129524 593__ $$aPhysics and Astronomy (miscellaneous)$$c2023$$dQ4 000129524 593__ $$aElectronic, Optical and Magnetic Materials$$c2023$$dQ4 000129524 594__ $$a2.2$$b2023 000129524 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000129524 700__ $$0(orcid)0000-0002-7516-3029$$aMarcellán, Maria Concepción$$uUniversidad de Zaragoza 000129524 700__ $$0(orcid)0000-0002-3979-4528$$aRemón, Laura$$uUniversidad de Zaragoza 000129524 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica 000129524 773__ $$g4, 4 (2023), 584-594$$pOptics (Basel)$$tOptics (Basel)$$x2673-3269 000129524 8564_ $$s3482827$$uhttps://zaguan.unizar.es/record/129524/files/texto_completo.pdf$$yVersión publicada 000129524 8564_ $$s2663639$$uhttps://zaguan.unizar.es/record/129524/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000129524 909CO $$ooai:zaguan.unizar.es:129524$$particulos$$pdriver 000129524 951__ $$a2024-07-31-10:09:03 000129524 980__ $$aARTICLE