Resumen: Scrapie, a naturally occurring prion disease affecting goats and sheep, comprises classical and atypical forms, with classical scrapie being the archetype of transmissible spongiform encephalopathies. This review explores the challenges of scrapie diagnosis and the utility of various biomarkers and their potential implications for human prion diseases. Understanding these biomarkers in the context of scrapie may enable earlier prion disease diagnosis in humans, which is crucial for effective intervention. Research on scrapie biomarkers bridges the gap between veterinary and human medicine, offering hope for the early detection and improved management of prion diseases. Idioma: Inglés DOI: 10.3390/pathogens12121399 Año: 2023 Publicado en: Pathogens 12, 12 (2023), 1399 [15 pp.] ISSN: 2076-0817 Factor impacto JCR: 3.3 (2023) Categ. JCR: MICROBIOLOGY rank: 70 / 161 = 0.435 (2023) - Q2 - T2 Factor impacto CITESCORE: 6.4 - Molecular Biology (Q2) - Infectious Diseases (Q2) - Microbiology (medical) (Q2) - Immunology and Microbiology (all) (Q2) - Immunology and Allergy (Q2)