000129581 001__ 129581
000129581 005__ 20240731103419.0
000129581 0247_ $$2doi$$a10.3390/s23239454
000129581 0248_ $$2sideral$$a135613
000129581 037__ $$aART-2023-135613
000129581 041__ $$aeng
000129581 100__ $$0(orcid)0000-0001-9710-0910$$aSannino, Andrea$$uUniversidad de Zaragoza
000129581 245__ $$aA Flexible PDMS-Based Optical Biosensor for Stretch Monitoring in Cardiac Tissue Samples
000129581 260__ $$c2023
000129581 5060_ $$aAccess copy available to the general public$$fUnrestricted
000129581 5203_ $$aCardiotoxicity, characterized by adverse impacts on normal heart function due to drug exposure, is a significant concern due to the potentially serious side effects associated with various pharmaceuticals. It is essential to detect the cardiotoxicity of a drug as early as possible in the testing phase of a medical composite. Therefore, there is a pressing need for more reliable in vitro models that accurately mimic the in vivo conditions of cardiac biopsies. In a functional beating heart, cardiac muscle cells are under the effect of static and cyclic stretches. It has been demonstrated that cultured cardiac biopsies can benefit from external mechanical loads that resemble the in vivo condition, increasing the probability of cardiotoxicity detection in the early testing stages. In this work, a biosensor is designed and fabricated to allow for stretch monitoring in biopsies and tissue cultures using an innovative sensing mechanism. The detection setup is based on a biocompatible, thin, flexible membrane—where the samples are attached—which is used as an optical waveguide to detect pressure-caused shape changes and stretches. Various prototypes have been fabricated with a cost-effective process, and different measurements have been carried out to experimentally validate the proposed measurement technique. From these evaluations, stretches of up to 1.5% have been measured, but the performed simulations point towards the possibility of expanding the considered technique up to 10–30% stretches.
000129581 536__ $$9info:eu-repo/grantAgreement/ES/DGA/GEPM T23-23$$9info:eu-repo/grantAgreement/ES/DGA/LMP94_21$$9info:eu-repo/grantAgreement/ES/DGA/T39-23R$$9info:eu-repo/grantAgreement/EC/H2020/638284/EU/Is your heart aging well? A systems biology approach to characterize cardiac aging from the cell to the body surface/MODELAGE$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 638284-MODELAGE$$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-105674RB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/PID2022-140556OB-I00$$9info:eu-repo/grantAgreement/EUR/MICINN/TED2021-130459B-I00
000129581 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000129581 590__ $$a3.4$$b2023
000129581 592__ $$a0.786$$b2023
000129581 591__ $$aCHEMISTRY, ANALYTICAL$$b34 / 106 = 0.321$$c2023$$dQ2$$eT1
000129581 593__ $$aInstrumentation$$c2023$$dQ1
000129581 591__ $$aINSTRUMENTS & INSTRUMENTATION$$b24 / 76 = 0.316$$c2023$$dQ2$$eT1
000129581 593__ $$aAnalytical Chemistry$$c2023$$dQ1
000129581 591__ $$aENGINEERING, ELECTRICAL & ELECTRONIC$$b122 / 352 = 0.347$$c2023$$dQ2$$eT2
000129581 593__ $$aAtomic and Molecular Physics, and Optics$$c2023$$dQ1
000129581 593__ $$aInformation Systems$$c2023$$dQ2
000129581 593__ $$aMedicine (miscellaneous)$$c2023$$dQ2
000129581 593__ $$aBiochemistry$$c2023$$dQ2
000129581 593__ $$aElectrical and Electronic Engineering$$c2023$$dQ2
000129581 594__ $$a7.3$$b2023
000129581 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000129581 700__ $$0(orcid)0000-0003-4361-6676$$aVelarte, Antonio$$uUniversidad de Zaragoza
000129581 700__ $$0(orcid)0000-0003-1403-1505$$aOtín, Aránzazu$$uUniversidad de Zaragoza
000129581 700__ $$0(orcid)0000-0002-8007-5613$$aArtigas, José Ignacio$$uUniversidad de Zaragoza
000129581 700__ $$0(orcid)0000-0001-5348-924X$$aOliván-Viguera, Aida
000129581 7102_ $$15008$$2785$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Tecnología Electrónica
000129581 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000129581 773__ $$g23, 23 (2023), 9454 [17 pp.]$$pSensors$$tSensors$$x1424-8220
000129581 8564_ $$s11397744$$uhttps://zaguan.unizar.es/record/129581/files/texto_completo.pdf$$yVersión publicada
000129581 8564_ $$s2735607$$uhttps://zaguan.unizar.es/record/129581/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000129581 909CO $$ooai:zaguan.unizar.es:129581$$particulos$$pdriver
000129581 951__ $$a2024-07-31-10:08:18
000129581 980__ $$aARTICLE