Detection of classical BSE prions in asymptomatic cows after inoculation with atypical/Nor98 scrapie

Betancor, Marina (Universidad de Zaragoza) ; Marín, Belén (Universidad de Zaragoza) ; Otero, Alicia (Universidad de Zaragoza) ; Hedman, Carlos (Universidad de Zaragoza) ; Romero, Antonio (Universidad de Zaragoza) ; Barrio, Tomás ; Sevilla, Eloisa (Universidad de Zaragoza) ; Douet, Jean-Yves ; Huor, Alvina ; Badiola, Juan José (Universidad de Zaragoza) ; Andréoletti, Olivier ; Bolea, Rosa (Universidad de Zaragoza)

Resumen: The emergence of bovine spongiform encephalopathy (BSE) prions from atypical scrapie has been recently observed upon experimental transmission to rodent and swine models. This study aimed to assess whether the inoculation of atypical scrapie could induce BSE-like disease in cattle. Four calves were intracerebrally challenged with atypical scrapie. Animals were euthanized without clinical signs of prion disease and tested negative for PrPSc accumulation by immunohistochemistry and western blotting. However, an emergence of BSE-like prion seeding activity was detected during in vitro propagation of brain samples from the inoculated animals. These findings suggest that atypical scrapie may represent a potential source of BSE infection in cattle.

Idioma: Inglés

DOI: 10.1186/s13567-023-01225-2

Año: 2023

Publicado en: Veterinary Research 54, 89 (2023), 1-7
ISSN: 0928-4249

Factor impacto JCR: 3.7 (2023)

Categ. JCR: VETERINARY SCIENCES rank: 10 / 167 = 0.06 (2023) - Q1 - T1

Factor impacto CITESCORE: 7.0 - Veterinary (all) (Q1)

Factor impacto SCIMAGO: 0.907 - Veterinary (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/EUR/INTERREG-POCTEFA/EFA-148-16 REDPRION
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2021-125398OB-I00

Tipo y forma: Article (Published version)

Área (Departamento): Área Sanidad Animal (Dpto. Patología Animal)
Área (Departamento): Área Producción Animal (Dpto. Produc.Animal Cienc.Ali.)
Área (Departamento): Área Medicina y Cirugía Animal (Dpto. Patología Animal)