Dysfunction of Drosophila mitochondrial carrier homolog (Mtch) alters apoptosis and disturbs development

González, Cristina ; Martínez-Sánchez, Lidia ; Clemente, Paula ; Toivonen, Janne Markus (Universidad de Zaragoza) ; Arredondo, Juan José ; Fernández-Moreno, Miguel Ángel ; Carrodeguas, José Alberto (Universidad de Zaragoza)

Resumen: Mitochondrial carrier homologs 1 (MTCH1) and 2 (MTCH2) are orphan members of the mitochondrial transporter family SLC25. Human MTCH1 is also known as presenilin 1‐associated protein, PSAP. MTCH2 is a receptor for tBid and is related to lipid metabolism. Both proteins have been recently described as protein insertases of the outer mitochondrial membrane. We have depleted Mtch in Drosophila and show here that mutant flies are unable to complete development, showing an excess of apoptosis during pupation; this observation was confirmed by RNAi in Schneider cells. These findings are contrary to what has been described in humans. We discuss the implications in view of recent reports concerning the function of these proteins.

Idioma: Inglés

DOI: 10.1002/2211-5463.13742

Año: 2023

Publicado en: FEBS openbio 14, 2 (2023), 276-289
ISSN: 2211-5463

Factor impacto JCR: 2.8 (2023)

Categ. JCR: BIOCHEMISTRY & MOLECULAR BIOLOGY rank: 184 / 313 = 0.588 (2023) - Q3 - T2

Factor impacto CITESCORE: 5.1 - Biochemistry, Genetics and Molecular Biology (all) (Q2)

Factor impacto SCIMAGO: 0.789 - Biochemistry, Genetics and Molecular Biology (miscellaneous) (Q2)

Financiación: info:eu-repo/grantAgreement/ES/MICINN/BFU2009-11800
Financiación: info:eu-repo/grantAgreement/ES/MINECO/RYC-2011-08363
Financiación: info:eu-repo/grantAgreement/ES/UZ/UZ2010-BIO-03

Tipo y forma: Article (Published version)

Área (Departamento): Área Genética (Dpto. Anatom.,Embri.Genét.Ani.)
Área (Departamento): Área Biología Celular (Dpto. Bioq.Biolog.Mol. Celular)