000130162 001__ 130162
000130162 005__ 20241125101128.0
000130162 0247_ $$2doi$$a10.1002/alz.12962
000130162 0248_ $$2sideral$$a132786
000130162 037__ $$aART-2023-132786
000130162 041__ $$aeng
000130162 100__ $$aGong, Jessica
000130162 245__ $$aSex differences in dementia risk and risk factors: Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium
000130162 260__ $$c2023
000130162 5060_ $$aAccess copy available to the general public$$fUnrestricted
000130162 5203_ $$aIntroduction
Sex differences in dementia risk, and risk factor (RF) associations with dementia, remain uncertain across diverse ethno-regional groups.
Methods
A total of 29,850 participants (58% women) from 21 cohorts across six continents were included in an individual participant data meta-analysis. Sex-specific hazard ratios (HRs), and women-to-men ratio of hazard ratios (RHRs) for associations between RFs and all-cause dementia were derived from mixed-effect Cox models.
Results
Incident dementia occurred in 2089 (66% women) participants over 4.6 years (median). Women had higher dementia risk (HR, 1.12 [1.02, 1.23]) than men, particularly in low- and lower-middle-income economies. Associations between longer education and former alcohol use with dementia risk (RHR, 1.01 [1.00, 1.03] per year, and 0.55 [0.38, 0.79], respectively) were stronger for men than women; otherwise, there were no discernible sex differences in other RFs.
Discussion
Dementia risk was higher in women than men, with possible variations by country-level income settings, but most RFs appear to work similarly in women and men.
000130162 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/B15-17R$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/01-0255$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/03-0815$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/06-0617$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/12-02254$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/16-00896$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/19-01874$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/94-1562$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/97-1321E$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/98-0103
000130162 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000130162 590__ $$a13.1$$b2023
000130162 592__ $$a3.226$$b2023
000130162 591__ $$aCLINICAL NEUROLOGY$$b5 / 280 = 0.018$$c2023$$dQ1$$eT1
000130162 593__ $$aEpidemiology$$c2023$$dQ1
000130162 593__ $$aCellular and Molecular Neuroscience$$c2023$$dQ1
000130162 593__ $$aDevelopmental Neuroscience$$c2023$$dQ1
000130162 593__ $$aPsychiatry and Mental Health$$c2023$$dQ1
000130162 593__ $$aHealth Policy$$c2023$$dQ1
000130162 593__ $$aNeurology (clinical)$$c2023$$dQ1
000130162 593__ $$aGeriatrics and Gerontology$$c2023$$dQ1
000130162 594__ $$a14.5$$b2023
000130162 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000130162 700__ $$aHarris, Katie
000130162 700__ $$aLipnicki, Darren M.
000130162 700__ $$aCastro-Costa, Erico
000130162 700__ $$aLima-Costa, Maria Fernanda
000130162 700__ $$aDiniz, Breno S.
000130162 700__ $$aXiao, Shifu
000130162 700__ $$aLipton, Richard B.
000130162 700__ $$aKatz, Mindy J.
000130162 700__ $$aWang, Cuiling
000130162 700__ $$aPreux, Pierre-Marie
000130162 700__ $$aGuerchet, Maëlenn
000130162 700__ $$aGbessemehlan, Antoine
000130162 700__ $$aRitchie, Karen
000130162 700__ $$aAncelin, Marie-Laure
000130162 700__ $$aSkoog, Ingmar
000130162 700__ $$aNajar, Jenna
000130162 700__ $$aSterner, Therese Rydberg
000130162 700__ $$aScarmeas, Nikolaos
000130162 700__ $$aYannakoulia, Mary
000130162 700__ $$aKosmidis, Mary H.
000130162 700__ $$aGuaita, Antonio
000130162 700__ $$aRolandi, Elena
000130162 700__ $$aDavin, Annalisa
000130162 700__ $$aGureje, Oye
000130162 700__ $$aTrompet, Stella
000130162 700__ $$aGussekloo, Jacobijn
000130162 700__ $$aRiedel-Heller, Steffi
000130162 700__ $$aPabst, Alexander
000130162 700__ $$aRöhr, Susanne
000130162 700__ $$aShahar, Suzana
000130162 700__ $$aSingh, Devinder Kaur Ajit
000130162 700__ $$aRivan, Nurul Fatin Malek
000130162 700__ $$avan Boxtel, Martin
000130162 700__ $$aKöhler, Sebastian
000130162 700__ $$aGanguli, Mary
000130162 700__ $$aChang, Chung-Chou
000130162 700__ $$aJacobsen, Erin
000130162 700__ $$aHaan, Mary
000130162 700__ $$aDing, Ding
000130162 700__ $$aZhao, Qianhua
000130162 700__ $$aXiao, Zhenxu
000130162 700__ $$aNarazaki, Kenji
000130162 700__ $$aChen, Tao
000130162 700__ $$aChen, Sanmei
000130162 700__ $$aNg, Tze Pin
000130162 700__ $$aGwee, Xinyi
000130162 700__ $$aNumbers, Katya
000130162 700__ $$aMather, Karen A.
000130162 700__ $$aScazufca, Marcia
000130162 700__ $$0(orcid)0000-0002-9098-655X$$aLobo, Antonio$$uUniversidad de Zaragoza
000130162 700__ $$0(orcid)0000-0003-2284-7862$$aDe-la-Cámara, Concepción$$uUniversidad de Zaragoza
000130162 700__ $$0(orcid)0000-0002-1252-2397$$aLobo, Elena$$uUniversidad de Zaragoza
000130162 700__ $$aSachdev, Perminder S.
000130162 700__ $$aBrodaty, Henry
000130162 700__ $$aHackett, Maree L.
000130162 700__ $$aPeters, Sanne A. E.
000130162 700__ $$aWoodward, Mark
000130162 700__ $$a
000130162 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000130162 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000130162 773__ $$g19, 8 (2023), 3365-3378$$pAlzheimers & Dementia$$tAlzheimers & Dementia$$x1552-5260
000130162 8564_ $$s1203728$$uhttps://zaguan.unizar.es/record/130162/files/texto_completo.pdf$$yVersión publicada$$zinfo:eu-repo/semantics/openAccess
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000130162 951__ $$a2024-11-22-11:58:19
000130162 980__ $$aARTICLE