Sex differences in dementia risk and risk factors: Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium

Gong, Jessica ; Harris, Katie ; Lipnicki, Darren M. ; Castro-Costa, Erico ; Lima-Costa, Maria Fernanda ; Diniz, Breno S. ; Xiao, Shifu ; Lipton, Richard B. ; Katz, Mindy J. ; Wang, Cuiling ; Preux, Pierre-Marie ; Guerchet, Maëlenn ; Gbessemehlan, Antoine ; Ritchie, Karen ; Ancelin, Marie-Laure ; Skoog, Ingmar ; Najar, Jenna ; Sterner, Therese Rydberg ; Scarmeas, Nikolaos ; Yannakoulia, Mary ; Kosmidis, Mary H. ; Guaita, Antonio ; Rolandi, Elena ; Davin, Annalisa ; Gureje, Oye ; Trompet, Stella ; Gussekloo, Jacobijn ; Riedel-Heller, Steffi ; Pabst, Alexander ; Röhr, Susanne ; Shahar, Suzana ; Singh, Devinder Kaur Ajit ; Rivan, Nurul Fatin Malek ; van Boxtel, Martin ; Köhler, Sebastian ; Ganguli, Mary ; Chang, Chung-Chou ; Jacobsen, Erin ; Haan, Mary ; Ding, Ding ; Zhao, Qianhua ; Xiao, Zhenxu ; Narazaki, Kenji ; Chen, Tao ; Chen, Sanmei ; Ng, Tze Pin ; Gwee, Xinyi ; Numbers, Katya ; Mather, Karen A. ; Scazufca, Marcia ; Lobo, Antonio (Universidad de Zaragoza) ; De-la-Cámara, Concepción (Universidad de Zaragoza) ; Lobo, Elena (Universidad de Zaragoza) ; Sachdev, Perminder S. ; Brodaty, Henry ; Hackett, Maree L. ; Peters, Sanne A. E. ; Woodward, Mark ;

Resumen: Introduction
Sex differences in dementia risk, and risk factor (RF) associations with dementia, remain uncertain across diverse ethno-regional groups.

Methods
A total of 29,850 participants (58% women) from 21 cohorts across six continents were included in an individual participant data meta-analysis. Sex-specific hazard ratios (HRs), and women-to-men ratio of hazard ratios (RHRs) for associations between RFs and all-cause dementia were derived from mixed-effect Cox models.

Results
Incident dementia occurred in 2089 (66% women) participants over 4.6 years (median). Women had higher dementia risk (HR, 1.12 [1.02, 1.23]) than men, particularly in low- and lower-middle-income economies. Associations between longer education and former alcohol use with dementia risk (RHR, 1.01 [1.00, 1.03] per year, and 0.55 [0.38, 0.79], respectively) were stronger for men than women; otherwise, there were no discernible sex differences in other RFs.

Discussion
Dementia risk was higher in women than men, with possible variations by country-level income settings, but most RFs appear to work similarly in women and men.

Idioma: Inglés

DOI: 10.1002/alz.12962

Año: 2023

Publicado en: Alzheimers & Dementia 19, 8 (2023), 3365-3378
ISSN: 1552-5260

Factor impacto JCR: 13.1 (2023)

Categ. JCR: CLINICAL NEUROLOGY rank: 5 / 280 = 0.018 (2023) - Q1 - T1

Factor impacto CITESCORE: 14.5 - Geriatrics and Gerontology (Q1) - Psychiatry and Mental Health (Q1) - Health Policy (Q1) - Neurology (clinical) (Q1) - Epidemiology (Q1) - Developmental Neuroscience (Q1) - Cellular and Molecular Neuroscience (Q1)

Factor impacto SCIMAGO: 3.226 - Epidemiology (Q1) - Cellular and Molecular Neuroscience (Q1) - Developmental Neuroscience (Q1) - Psychiatry and Mental Health (Q1) - Health Policy (Q1) - Neurology (clinical) (Q1) - Geriatrics and Gerontology (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA-FEDER/B15-17R
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/01-0255
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/03-0815
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/06-0617
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/12-02254
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/16-00896
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/19-01874
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/94-1562
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/97-1321E
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/98-0103

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Area Psiquiatría (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Área Medic.Prevent.Salud Públ. (Dpto. Microb.Ped.Radio.Sal.Pú.)