Sex Differences in Longitudinal Trajectories of Cognitive Aging in Zaragoza, Spain

Lobo, Elena (Universidad de Zaragoza) ; Lobo, Antonio (Universidad de Zaragoza) ; Gracia-García, Patricia (Universidad de Zaragoza) ; López-Antón, Raúl (Universidad de Zaragoza) ; Saz, Pedro (Universidad de Zaragoza) ; De la Cámara, Concepción (Universidad de Zaragoza)

Resumen: Objectives: The objective of this study was to document the longitudinal trajectories of cognitive aging in a sample of cognitively healthy subjects of 55 years or older. The following differences between men and women were hypothesized: 1) in the cognitive loss through aging, 2) in the distinct trajectories identified; and 3) in the predictors associated with the identified trajectories. Design and setting: A 4-wave, population-based study in Zaragoza, Spain (1994-2006). Participants: A total of 2,403 individuals aged 55+ years, cognitively healthy at baseline. Measurements: All participants had at least three measurements with the Mini-Mental State Examination (MMSE). Validated Spanish versions of international instruments were used for assessment. Random effects linear panel regression model for analyzing differences by sex in MMSE scores through aging were performed, and growth mixture models (GMM) applied independently for each sex for modeling the longitudinal cognitive trajectories. Results: Women showed lower mean MMSE scores in all phases and significantly higher loss in the MMSE from phases 2 to 3 and 3 to 4. The best fitting age-adjusted model of the cognitive trajectories was a 4-class GMM in men and a 3-class in women. Education was a predictor of cognitive trajectories in both men and women. Dependence on iADLs and alcohol status were predictors only for men, and depression and diabetes only for women. Conclusions: The identified differences by sex in cognitive trajectories and their associated factors suggest that men and women may require a different strategy when addressing cognitive aging.

Idioma: Inglés

DOI: 10.1016/j.jagp.2023.04.012

Año: 2023

Publicado en: American journal of geriatric psychiatry 31, 10 (2023), 796-807
ISSN: 1064-7481

Factor impacto JCR: 4.4 (2023)

Categ. JCR: GERIATRICS & GERONTOLOGY rank: 16 / 74 = 0.216 (2023) - Q1 - T1
Categ. JCR: GERONTOLOGY rank: 6 / 47 = 0.128 (2023) - Q1 - T1
Categ. JCR: PSYCHIATRY rank: 48 / 279 = 0.172 (2023) - Q1 - T1
Categ. JCR: PSYCHIATRY rank: 48 / 279 = 0.172 (2023) - Q1 - T1

Factor impacto CITESCORE: 13.0 - Psychiatry and Mental Health (Q1) - Geriatrics and Gerontology (Q1)

Factor impacto SCIMAGO: 1.913 - Psychiatry and Mental Health (Q1) - Geriatrics and Gerontology (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/B15-17R
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/G03-128
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/01-0255
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/06-0617
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/98-0103
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-MINECO/PI16-00896
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI19-00948
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/03-0815
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/12-02254
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/16-00896
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/94-1562
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/97-1321E

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Psicología Básica (Dpto. Psicología y Sociología)
Área (Departamento): Area Psiquiatría (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Área Medic.Prevent.Salud Públ. (Dpto. Microb.Ped.Radio.Sal.Pú.)