Evaluation of Institut Georges Lopez-1 preservation solution in pig pancreas transplantation: a pilot study

García-Gil, Francisco A ; Fuentes-Broto, Lorena (Universidad de Zaragoza) ; Albendea, Carlos D. ; Serrano, María Trinidad (Universidad de Zaragoza) ; Roselló-Catafau, Joan ; Lampreave, Fermín ; López-Pingarrón, Laura ; Escartín, Jorge ; Soria, Joaquín ; Garcia, ,Joaquín J ; Fernández-Cruz, Laureano

Resumen: Background. Institut Georges Lopez-1 preservation solution (IGL-1) is an emerging extracellular-type electrolyte solution, low in viscosity, containing polyethylene glycol 35 as a colloid. Although IGL-1 has shown beneficial outcomes in kidney and liver preservation, this pilot study is the first to evaluate the efficacy of IGL-1 in pancreas transplantation (PT) compared with the University of Wisconsin solution (UW)
Methods. Sixteen Landrace pigs underwent allogeneic PT with 16 hr of cold ischemia. Grafts were preserved with IGL-1 (n=8) or UW (n=8). No immunosuppression was administered. We analyzed graft function, the acute-phase response, and oxidative stress in the pancreatic graft monitoring membrane fluidity and lipid peroxidation@@@Results. All eight grafts with IGL-1, but only six with UW, were functioning. Graft failures with UW resulted from graft thrombosis. There were no differences between the two solutions in the number of normoglycemic days (IGL-1: 11.5T6.2 versus UW: 8.5T4.4 days, P=0.1357), nor in lipid peroxidation during 16-hr cold ischemia (P=0.672), or reperfusion (P=0.185), but IGL-1 prevented changes in membrane fluidity after reperfusion when compared with UW (P=0.026)
Conclusion. IGL-1 offered the same degree of safety and effectiveness as UW in our model of pig PT with 16 hr of cold ischemia.

Idioma: Inglés

DOI: 10.1097/TP.0000000000000050

Año: 2014

Publicado en: Transplantation 97, 9 (2014), 901-907
ISSN: 0041-1337

Factor impacto JCR: 3.828 (2014)

Categ. JCR: SURGERY rank: 17 / 196 = 0.087 (2014) - Q1 - T1
Categ. JCR: TRANSPLANTATION rank: 4 / 25 = 0.16 (2014) - Q1 - T1
Categ. JCR: IMMUNOLOGY rank: 43 / 147 = 0.293 (2014) - Q2 - T1

Financiación: info:eu-repo/grantAgreement/ES/MICINN/ISCIII-PI10-2877
Financiación: info:eu-repo/grantAgreement/ES/MICINN/ISCIII-RD06-0013-1017

Tipo y forma: Article (Published version)

Área (Departamento): Área Fisiología (Dpto. Farmacología y Fisiolog.)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)