000130271 001__ 130271
000130271 005__ 20240124152850.0
000130271 0247_ $$2doi$$a10.1023/A:1015021603681
000130271 0248_ $$2sideral$$a51908
000130271 037__ $$aART-2002-51908
000130271 041__ $$aeng
000130271 100__ $$0(orcid)0000-0002-7119-2244$$aSerrano, Trinidad
000130271 245__ $$aBleeding duodenal ulcer and association with polymorphism of endothelial constitutive nitric oxide synthase gene.
000130271 260__ $$c2002
000130271 5203_ $$aNitric oxide (NO) exerts both protective and proinflammatory actions in the gastrointestinal tract. Enhanced gastric NO synthase (NOS) activity has been shown in duodenal ulcer patients. Recently, intron-4 polymorphism of the endothelial constitutive (ec) NOS gene has been associated with some pathological conditions. Our aim was to determine the genotype and allele frequencies of the ecNOS4 polymorphism in peptic ulcer patients. The distribution of the polymorphism ecNOS4a/b was studied in 188 ulcer patients and 120 healthy controls, from genomic DNA. Genotypes ab, bb, and aa and allele frequency were similar in both peptic ulcer patients and controls, and no differences were found when patients and controls were analyzed according to the presence of several etiological factors. However, alelle “a” carrier status was associated with decreased risk of bleeding in duodenal ulcer patients (OR 0.49; 95% CI 0.25– 0.95; P 0.03). In conclusion, this ecNOS4 polymorphism gene
could be related to susceptibility of duodenal ulcer patients to bleeding. KEY WORDS: endothelial nitric oxide synthase; DNA polymorphism; peptic ulcer.
000130271 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000130271 590__ $$a1.438$$b2002
000130271 591__ $$aGASTROENTEROLOGY & HEPATOLOGY$$b27 / 45 = 0.6$$c2002$$dQ3$$eT2
000130271 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000130271 700__ $$0(orcid)0000-0001-5813-3445$$aPiazuelo, Elena
000130271 700__ $$0(orcid)0000-0001-5134-1006$$aBenito, Rafael$$uUniversidad de Zaragoza
000130271 700__ $$aSantolaria, Santos
000130271 700__ $$0(orcid)0000-0001-5932-2889$$aLanas, Angel$$uUniversidad de Zaragoza
000130271 7102_ $$11008$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Microbiología
000130271 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000130271 773__ $$g47, 5 (2002), 996-1000$$pDig. dis. sci.$$tDigestive Diseases and Sciences$$x0163-2116
000130271 8564_ $$s1233697$$uhttps://zaguan.unizar.es/record/130271/files/texto_completo.pdf$$yVersión publicada
000130271 8564_ $$s2456301$$uhttps://zaguan.unizar.es/record/130271/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000130271 909CO $$ooai:zaguan.unizar.es:130271$$particulos$$pdriver
000130271 951__ $$a2024-01-24-14:58:47
000130271 980__ $$aARTICLE