Bleeding duodenal ulcer and association with polymorphism of endothelial constitutive nitric oxide synthase gene.

Serrano, Trinidad ; Piazuelo, Elena ; Benito, Rafael (Universidad de Zaragoza) ; Santolaria, Santos ; Lanas, Angel (Universidad de Zaragoza)

Resumen: Nitric oxide (NO) exerts both protective and proinflammatory actions in the gastrointestinal tract. Enhanced gastric NO synthase (NOS) activity has been shown in duodenal ulcer patients. Recently, intron-4 polymorphism of the endothelial constitutive (ec) NOS gene has been associated with some pathological conditions. Our aim was to determine the genotype and allele frequencies of the ecNOS4 polymorphism in peptic ulcer patients. The distribution of the polymorphism ecNOS4a/b was studied in 188 ulcer patients and 120 healthy controls, from genomic DNA. Genotypes ab, bb, and aa and allele frequency were similar in both peptic ulcer patients and controls, and no differences were found when patients and controls were analyzed according to the presence of several etiological factors. However, alelle “a” carrier status was associated with decreased risk of bleeding in duodenal ulcer patients (OR 0.49; 95% CI 0.25– 0.95; P 0.03). In conclusion, this ecNOS4 polymorphism gene
could be related to susceptibility of duodenal ulcer patients to bleeding. KEY WORDS: endothelial nitric oxide synthase; DNA polymorphism; peptic ulcer.

Idioma: Inglés

DOI: 10.1023/A:1015021603681

Año: 2002

Publicado en: Digestive Diseases and Sciences 47, 5 (2002), 996-1000
ISSN: 0163-2116

Factor impacto JCR: 1.438 (2002)

Categ. JCR: GASTROENTEROLOGY & HEPATOLOGY rank: 27 / 45 = 0.6 (2002) - Q3 - T2

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Microbiología (Dpto. Microb.Med.Pr.,Sal.Públ.)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)