In vitro osteoinduction of human mesenchymal stem cells in biomimetic surface modified titanium alloy implants

Santander, S. (Universidad de Zaragoza) ; Alcaine, C. ; Lyahyai, J. ; Pérez, M. A. (Universidad de Zaragoza) ; Rodellar, C. (Universidad de Zaragoza) ; Doblaré, M. (Universidad de Zaragoza) ; Ochoa, I. (Universidad de Zaragoza)

Resumen: Interaction between cells and implant surface is crucial for clinical success. This interaction and the associated surface treatment are essential for achieving a fast osseointegration process. Several studies of different topographical or chemical surface modifications have been proposed previously in literature. The Biomimetic Advanced Surface (BAS) topography is a combination of a shot blasting and anodizing procedure. Macroroughness, microporosity of titanium oxide and Calcium/Phosphate ion deposition is obtained. Human mesenchymal stem cells (hMCSs) response in vitro to this treatment has been evaluated. The results obtained show an improved adhesion capacity and a higher proliferation rate when hMSCs are cultured on treated surfaces. This biomimetic modification of the titanium surface induces the expression of osteblastic differentiation markers (RUNX2 and Osteopontin) in the absence of any externally provided differentiation factor. As a main conclusion, our biomimetic surface modification could lead to a substantial improvement in osteoinduction in titanium alloy implants.

Idioma: Inglés

DOI: 10.4012/dmj.2012-015-r

Año: 2014

Publicado en: DENTAL MATERIALS JOURNAL 33, 3 (2014), 305-312
ISSN: 0287-4547

Factor impacto JCR: 0.968 (2014)

Categ. JCR: DENTISTRY, ORAL SURGERY & MEDICINE rank: 62 / 87 = 0.713 (2014) - Q3 - T3
Categ. JCR: MATERIALS SCIENCE, BIOMATERIALS rank: 30 / 33 = 0.909 (2014) - Q4 - T3

Tipo y forma: Article (Published version)

Área (Departamento): Área Genética (Dpto. Anatom.,Embri.Genét.Ani.)
Área (Departamento): Area Histología (Dpto. Anatom.Histolog.Humanas)
Área (Departamento): Área Farmacología (Dpto. Farmacología y Fisiolog.)
Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)