MALT Lymphoma Involving the Kidney

Garcia, Mar ; Konoplev, Sergej ; Morosan, Cristian ; Abruzzo, Lynne V. ; Bueso-Ramos, Carlos E. ; Medeiros, L. Jeffrey

Resumen: Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) can arise at any anatomic site, but involvement of the kidney is rare. We describe 10 cases of kidney MALT lymphoma, including 6 localized cases. No predisposing inflammatory conditions were identified, with the possible exception of coexistent renal Actinomyces infection in 1 case. We performed fluorescence in situ hybridization (FISH) using a malt1 break-apart probe in 7 cases. A malt1 gene rearrangement was identified in 1 case (14%). This case was further assessed by FISH using an IgH break-apart probe that showed IgH gene rearrangement. These results are suggestive of the t(14;18) involving malt1 and IgH. Immunostaining for NF- ¿B p65 showed nuclear positivity, consistent with NF- ¿B activation, in 3 of 5 cases assessed. Our results indicate that kidney MALT lymphomas share similarities with MALT lymphomas arising at other sites in that MALT lymphoma–associated translocations and NF- ¿B activation occur in a subset of cases.

Idioma: Inglés

DOI: 10.1309/0t2ukukv91w3qr6w

Año: 2007

Publicado en: AMERICAN JOURNAL OF CLINICAL PATHOLOGY 128, 3 (2007), 464-473
ISSN: 0002-9173

Factor impacto JCR: 2.629 (2007)

Categ. JCR: PATHOLOGY rank: 19 / 65 = 0.292 (2007) - Q2 - T1

Tipo y forma: Artículo