Myeloid Sarcoma Involving the Gynecologic Tract

Garcia, Mar Garcia ; Deavers, Michael T. ; Knoblock, Ronald J. ; Chen, Weina ; Tsimberidou, Apostolia M. ; Manning, John T. ; Medeiros, L. Jeffrey

Resumen: Myeloid sarcoma can involve any anatomic site, but involvement of the gynecologic tract is uncommon. We describe 11 women, 17 to 60 years old, with myeloid sarcoma involving the gynecologic tract, including 5 patients in whom myeloid sarcoma presented as an isolated mass. The uterus was the most frequently involved anatomic site, in 8 patients (5 corpus, 3 cervix). Each neoplasm diffusely infiltrated normal structures, and, cytologically 7 tumors were immature, 3 were differentiated, and 1 was blastic. In 9 cases assessed, immunohistochemical stains showed that all neoplasms were positive for myeloperoxidase and lysozyme; CD117 was positive in 7 of 8 cases, and cytochemical staining for naphthol AS-D chloroacetate was positive in all 6 neoplasms analyzed. Following chemotherapy, complete remission and long-term survival were achieved in a subset of patients, as was particularly true for 2 patients (cases 8 and 10), with complete remission 12.5 and 31 years after diagnosis, respectively.

Idioma: Inglés

DOI: 10.1309/h9mm21fpt7ybl3pw

Año: 2006

Publicado en: AMERICAN JOURNAL OF CLINICAL PATHOLOGY 125, 5 (2006), 783-790
ISSN: 0002-9173

Factor impacto JCR: 2.939 (2006)

Categ. JCR: PATHOLOGY rank: 12 / 64 = 0.188 (2006) - Q1 - T1

Tipo y forma: Article