Aqueous seeded RAFT polymerization for the preparation of self-assemblies containing nucleobase analogues

Abad, Miriam (Universidad de Zaragoza) ; Nardi, Martina ; Oriol, Luis (Universidad de Zaragoza) ; Piñol, Milagros (Universidad de Zaragoza) ; Blasco, Eva

Resumen: Self-assemblies containing the nucleobase analogue 2,6-diacylaminopyridine (DAP) have been successfully prepared for the first time by aqueous seeded RAFT polymerization in high concentrations. For this purpose, a diblock copolymer containing poly(ethylene glycol) (PEG) and DAP polymethacrylate blocks was used as a macro-chain-transfer agent (PEG124-b-PDAP9-CTA) for the polymerization of 2-hydroxypropyl methacrylate (HPMA) in water. From the systematic variation of the degree of polymerization and solid concentration, a phase diagram has been generated that correlates both variables with the morphologies of this new system. Self-assemblies have been characterized by TEM and DLS, observing morphologies from low to high order (from spherical micelles to worms and to vesicles). Self-assembly morphologies are stable for almost a year, except in the case of worms that turn into spherical micelles after a few weeks. In addition, H-bonding supramolecular functionalization of the DAP repeating units during aqueous seeded RAFT polymerization has been examined by functionalization with a cross-linker with four thymine groups. Finally, the loading and the subsequent release of Nile Red have been proven in both supramolecular cross-linked and non-cross-linked self-assemblies.

Idioma: Inglés

DOI: 10.1039/d2py01250b

Año: 2023

Publicado en: POLYMER CHEMISTRY 14, 1 (2023), 71-80
ISSN: 1759-9954

Factor impacto JCR: 4.1 (2023)

Categ. JCR: POLYMER SCIENCE rank: 27 / 94 = 0.287 (2023) - Q2 - T1

Factor impacto CITESCORE: 8.6 - Organic Chemistry (Q1) - Polymers and Plastics (Q1) - Bioengineering (Q1) - Biochemistry (Q1)

Factor impacto SCIMAGO: 0.969 - Biomedical Engineering (Q1) - Organic Chemistry (Q1) - Polymers and Plastics (Q1) - Bioengineering (Q2) - Biochemistry (Q2)

Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/E47-17R
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2021-126132NB-I00
Financiación: info:eu-repo/grantAgreement/ES/MINECO/MAT2017-84838-P

Tipo y forma: Artículo (PostPrint)

Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)