000130602 001__ 130602
000130602 005__ 20241125101128.0
000130602 0247_ $$2doi$$a10.1039/d2py01250b
000130602 0248_ $$2sideral$$a132733
000130602 037__ $$aART-2023-132733
000130602 041__ $$aeng
000130602 100__ $$0(orcid)0000-0002-8677-3316$$aAbad, Miriam$$uUniversidad de Zaragoza
000130602 245__ $$aAqueous seeded RAFT polymerization for the preparation of self-assemblies containing nucleobase analogues
000130602 260__ $$c2023
000130602 5060_ $$aAccess copy available to the general public$$fUnrestricted
000130602 5203_ $$aSelf-assemblies containing the nucleobase analogue 2,6-diacylaminopyridine (DAP) have been successfully prepared for the first time by aqueous seeded RAFT polymerization in high concentrations. For this purpose, a diblock copolymer containing poly(ethylene glycol) (PEG) and DAP polymethacrylate blocks was used as a macro-chain-transfer agent (PEG124-b-PDAP9-CTA) for the polymerization of 2-hydroxypropyl methacrylate (HPMA) in water. From the systematic variation of the degree of polymerization and solid concentration, a phase diagram has been generated that correlates both variables with the morphologies of this new system. Self-assemblies have been characterized by TEM and DLS, observing morphologies from low to high order (from spherical micelles to worms and to vesicles). Self-assembly morphologies are stable for almost a year, except in the case of worms that turn into spherical micelles after a few weeks. In addition, H-bonding supramolecular functionalization of the DAP repeating units during aqueous seeded RAFT polymerization has been examined by functionalization with a cross-linker with four thymine groups. Finally, the loading and the subsequent release of Nile Red have been proven in both supramolecular cross-linked and non-cross-linked self-assemblies.
000130602 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/E47-17R$$9info:eu-repo/grantAgreement/ES/MICINN/PID2021-126132NB-I00$$9info:eu-repo/grantAgreement/ES/MINECO/MAT2017-84838-P
000130602 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000130602 590__ $$a4.1$$b2023
000130602 592__ $$a0.969$$b2023
000130602 591__ $$aPOLYMER SCIENCE$$b27 / 95 = 0.284$$c2023$$dQ2$$eT1
000130602 593__ $$aBiomedical Engineering$$c2023$$dQ1
000130602 593__ $$aOrganic Chemistry$$c2023$$dQ1
000130602 593__ $$aPolymers and Plastics$$c2023$$dQ1
000130602 593__ $$aBioengineering$$c2023$$dQ2
000130602 593__ $$aBiochemistry$$c2023$$dQ2
000130602 594__ $$a8.6$$b2023
000130602 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000130602 700__ $$aNardi, Martina
000130602 700__ $$0(orcid)0000-0002-0922-5615$$aOriol, Luis$$uUniversidad de Zaragoza
000130602 700__ $$0(orcid)0000-0001-5556-2172$$aPiñol, Milagros$$uUniversidad de Zaragoza
000130602 700__ $$aBlasco, Eva
000130602 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000130602 773__ $$g14, 1 (2023), 71-80$$pPOLYMER CHEMISTRY$$tPOLYMER CHEMISTRY$$x1759-9954
000130602 8564_ $$s1750219$$uhttps://zaguan.unizar.es/record/130602/files/texto_completo.pdf$$yPostprint
000130602 8564_ $$s2349876$$uhttps://zaguan.unizar.es/record/130602/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000130602 909CO $$ooai:zaguan.unizar.es:130602$$particulos$$pdriver
000130602 951__ $$a2024-11-22-11:58:16
000130602 980__ $$aARTICLE