Developmental origins of Parkinson disease: improving the rodent models

Jiménez Salvador, Irene (Universidad de Zaragoza) ; Meade, Patricia (Universidad de Zaragoza) ; Iglesias, Eldris ; Bayona-Bafaluy, Pilar (Universidad de Zaragoza) ; Ruiz Pesini, Eduardo (Universidad de Zaragoza)

Resumen: Numerous pesticides are inhibitors of the oxidative phosphorylation system. Oxidative phosphorylation dysfunction adversely affects neurogenesis and often accompanies Parkinson disease. Since brain development occurs mainly in the prenatal period, early exposure to pesticides could alter the development of the nervous system and increase the risk of Parkinson disease. Different rodent models have been used to confirm this hypothesis. However, more precise considerations of the selected strain, the xenobiotic, its mode of administration, and the timing of animal analysis, are necessary to resemble the model to the human clinical condition and obtain more reliable results.

Idioma: Inglés

DOI: 10.1016/j.arr.2023.101880

Año: 2023

Publicado en: Ageing Research Reviews 86 (2023), 101880 [8 pp.]
ISSN: 1568-1637

Financiación: info:eu-repo/grantAgreement/ES/DGA/B33-20R
Financiación: info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón
Financiación: info:eu-repo/grantAgreement/ES/DGA/LMP22_21
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI21-00229

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)