Developmental origins of Parkinson disease: improving the rodent models
Jiménez Salvador, Irene (Universidad de Zaragoza) ; Meade, Patricia (Universidad de Zaragoza) ; Iglesias, Eldris ; Bayona-Bafaluy, Pilar (Universidad de Zaragoza) ; Ruiz Pesini, Eduardo (Universidad de Zaragoza)
Resumen: Numerous pesticides are inhibitors of the oxidative phosphorylation system. Oxidative phosphorylation dysfunction adversely affects neurogenesis and often accompanies Parkinson disease. Since brain development occurs mainly in the prenatal period, early exposure to pesticides could alter the development of the nervous system and increase the risk of Parkinson disease. Different rodent models have been used to confirm this hypothesis. However, more precise considerations of the selected strain, the xenobiotic, its mode of administration, and the timing of animal analysis, are necessary to resemble the model to the human clinical condition and obtain more reliable results.
Idioma: Inglés
DOI: 10.1016/j.arr.2023.101880
Año: 2023
Publicado en: Ageing Research Reviews 86 (2023), 101880 [8 pp.]
ISSN: 1568-1637
Factor impacto JCR: 12.5 (2023)
Categ. JCR: GERIATRICS & GERONTOLOGY rank: 3 / 74 = 0.041 (2023) - Q1 - T1
Categ. JCR: CELL BIOLOGY rank: 20 / 205 = 0.098 (2023) - Q1 - T1
Factor impacto CITESCORE: 19.8 - Biotechnology (Q1) - Biochemistry (Q1) - Neurology (Q1) - Molecular Biology (Q1) - Aging (Q1)
Factor impacto SCIMAGO: 3.376 - Aging (Q1) - Biochemistry (Q1) - Neurology (Q1) - Molecular Biology (Q1) - Biotechnology (Q1)
Financiación: info:eu-repo/grantAgreement/ES/DGA/B33-20R
Financiación: info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón
Financiación: info:eu-repo/grantAgreement/ES/DGA/LMP22_21
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI21-00229
Tipo y forma: Article (Published version)
Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material.
Exportado de SIDERAL (2024-11-22-11:58:54)
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Idioma: Inglés
DOI: 10.1016/j.arr.2023.101880
Año: 2023
Publicado en: Ageing Research Reviews 86 (2023), 101880 [8 pp.]
ISSN: 1568-1637
Factor impacto JCR: 12.5 (2023)
Categ. JCR: GERIATRICS & GERONTOLOGY rank: 3 / 74 = 0.041 (2023) - Q1 - T1
Categ. JCR: CELL BIOLOGY rank: 20 / 205 = 0.098 (2023) - Q1 - T1
Factor impacto CITESCORE: 19.8 - Biotechnology (Q1) - Biochemistry (Q1) - Neurology (Q1) - Molecular Biology (Q1) - Aging (Q1)
Factor impacto SCIMAGO: 3.376 - Aging (Q1) - Biochemistry (Q1) - Neurology (Q1) - Molecular Biology (Q1) - Biotechnology (Q1)
Financiación: info:eu-repo/grantAgreement/ES/DGA/B33-20R
Financiación: info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón
Financiación: info:eu-repo/grantAgreement/ES/DGA/LMP22_21
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI21-00229
Tipo y forma: Article (Published version)
Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material. Exportado de SIDERAL (2024-11-22-11:58:54)
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Record created 2024-01-26, last modified 2024-11-25