000130642 001__ 130642
000130642 005__ 20240130150401.0
000130642 0247_ $$2doi$$a10.1007/s00384-016-2731-2
000130642 0248_ $$2sideral$$a96909
000130642 037__ $$aART-2017-96909
000130642 041__ $$aeng
000130642 100__ $$0(orcid)0000-0002-1557-7545$$aMartínez, A.B.$$uUniversidad de Zaragoza
000130642 245__ $$aA model for lymphocyte activation in open versus laparoscopic surgery in colorectal cancer patients in enhanced recovery after surgery (ERAS) protocols
000130642 260__ $$c2017
000130642 5203_ $$aPurpose Given the high mortality and morbidity associated with colon cancer worldwide and the advantages inherent to the use of the laparoscopy technique with respect to open surgery in oncological colorectal surgery, a study was de- signed to observe and compare the lymphocyte activation model between open surgery (OS) and laparoscopic surgery (LS) for this type of patient as part of an ERAS protocol. Methods A prospective study was conducted with 38 patients who underwent surgery due to colorectal disease and were included in an ERAS protocol. The patients were divided into two groups: G1 (patients who had undergone OS; n = 19) and G2 (patients who had undergone LS; n = 19). The lymphocyte activation model was studied at three times: immediately prior to surgery and on post-operative days 1 and 3 (POD0, POD1 and POD3).
Results The Th lymphocyte activation markers studied (CD25, CD69, HLADR) exhibited a significantly higher mean value on POD0 for CD69 in OS than in LS (p = 0.037) and a significantly lower mean HLADR value on POD3 for OS than for LS (p = 0.040). No statistically significant differences were observed in either the evolution or in the mean values for the intracellular cytokines studied responsible for a Th1, Th2 or Th17 response. A Th1 response pattern was observed in both OS and LS.
Conclusions The lymphocyte activation model in OS and LS is a Th1 response in both cases. The findings for the Th lym- phocyte activation markers could indicate a better preserved immunity in LS with respect to OS.
000130642 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000130642 590__ $$a2.533$$b2017
000130642 591__ $$aSURGERY$$b61 / 200 = 0.305$$c2017$$dQ2$$eT1
000130642 591__ $$aGASTROENTEROLOGY & HEPATOLOGY$$b57 / 80 = 0.712$$c2017$$dQ3$$eT3
000130642 592__ $$a1.054$$b2017
000130642 593__ $$aGastroenterology$$c2017$$dQ2
000130642 655_4 $$ainfo:eu-repo/semantics/conferenceObject$$vinfo:eu-repo/semantics/publishedVersion
000130642 700__ $$0(orcid)0000-0002-3647-5679$$aLongás, J.$$uUniversidad de Zaragoza
000130642 700__ $$0(orcid)0000-0001-7964-1166$$aRamírez, J.M.$$uUniversidad de Zaragoza
000130642 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000130642 7102_ $$11005$$2410$$aUniversidad de Zaragoza$$bDpto. Farmacología y Fisiolog.$$cÁrea Fisiología
000130642 7102_ $$11004$$2090$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Cirugía
000130642 773__ $$g32, 6 (2017), 913-916$$pInt. j. colorectal dis.$$tInternational Journal of Colorectal Disease$$x0179-1958
000130642 8564_ $$s361377$$uhttps://zaguan.unizar.es/record/130642/files/texto_completo.pdf$$yVersión publicada
000130642 8564_ $$s2151535$$uhttps://zaguan.unizar.es/record/130642/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000130642 909CO $$ooai:zaguan.unizar.es:130642$$particulos$$pdriver
000130642 951__ $$a2024-01-30-14:04:33
000130642 980__ $$aARTICLE