Migration studies and toxicity evaluation of cyclic polyesters oligomers from food packaging adhesives
Ubeda, Sara (Universidad de Zaragoza) ; Aznar, Margarita (Universidad de Zaragoza) ; Rosenmai, Anna Kjerstine ; Vinggaard, Anne Marie ; Nerín, Cristina (Universidad de Zaragoza)
Resumen: Multilayer materials used in food packaging are commonly manufactured with a polyurethane adhesive layer in its structure that may contain cyclic esters oligomers as potential migrants. However, little is known about their toxicity. In this work, two cyclic esters of polyurethane are evaluated in migration from 20 multilayer packaging samples. They were composed by adipic acid (AA), diethylene glycol (DEG) and isophthalic acid (IPA) and their structure was AA-DEG and AA-DEG-IPA-DEG. The concentration of these compounds in migration exceeded the maximum level established by Regulation EU/10/2011 (10 ng g-1). Bioaccessibility of both compounds was evaluated by studying gastric and intestinal digestion. The studies showed that the concentration of the compounds decreased during digestion and that their hydrolysed molecules increased. Furthermore, endocrine activity in vitro assays were performed. A weak androgen receptor antagonism was identified, whereas no arylhydrocarbon receptor activity or binding to the thyroid hormone transport protein was found.
Idioma: Inglés
DOI: 10.1016/j.foodchem.2019.125918
Año: 2020
Publicado en: Food Chemistry 311 (2020), 125918 [10 pp.]
ISSN: 0308-8146
Factor impacto JCR: 7.514 (2020)
Categ. JCR: CHEMISTRY, APPLIED rank: 7 / 74 = 0.095 (2020) - Q1 - T1
Categ. JCR: NUTRITION & DIETETICS rank: 6 / 87 = 0.069 (2020) - Q1 - T1
Categ. JCR: FOOD SCIENCE & TECHNOLOGY rank: 7 / 143 = 0.049 (2020) - Q1 - T1
Factor impacto SCIMAGO: 1.772 - Analytical Chemistry (Q1) - Medicine (miscellaneous) (Q1) - Food Science (Q1)
Financiación: info:eu-repo/grantAgreement/ES/DGA/T53-17R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/AGL2015-67362-P
Financiación: info:eu-repo/grantAgreement/ES/MINECO/BES-2016-077159
Tipo y forma: Article (PostPrint)
Área (Departamento): Área Química Analítica (Dpto. Química Analítica)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material.
Exportado de SIDERAL (2024-01-31-19:19:23)
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Idioma: Inglés
DOI: 10.1016/j.foodchem.2019.125918
Año: 2020
Publicado en: Food Chemistry 311 (2020), 125918 [10 pp.]
ISSN: 0308-8146
Factor impacto JCR: 7.514 (2020)
Categ. JCR: CHEMISTRY, APPLIED rank: 7 / 74 = 0.095 (2020) - Q1 - T1
Categ. JCR: NUTRITION & DIETETICS rank: 6 / 87 = 0.069 (2020) - Q1 - T1
Categ. JCR: FOOD SCIENCE & TECHNOLOGY rank: 7 / 143 = 0.049 (2020) - Q1 - T1
Factor impacto SCIMAGO: 1.772 - Analytical Chemistry (Q1) - Medicine (miscellaneous) (Q1) - Food Science (Q1)
Financiación: info:eu-repo/grantAgreement/ES/DGA/T53-17R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/AGL2015-67362-P
Financiación: info:eu-repo/grantAgreement/ES/MINECO/BES-2016-077159
Tipo y forma: Article (PostPrint)
Área (Departamento): Área Química Analítica (Dpto. Química Analítica)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material. Exportado de SIDERAL (2024-01-31-19:19:23)
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Record created 2024-01-31, last modified 2024-01-31