000131116 001__ 131116 000131116 005__ 20241125101136.0 000131116 0247_ $$2doi$$a10.1016/j.mbs.2023.109088 000131116 0248_ $$2sideral$$a136706 000131116 037__ $$aART-2023-136706 000131116 041__ $$aeng 000131116 100__ $$0(orcid)0000-0002-8089-343X$$aBarrio, R.$$uUniversidad de Zaragoza 000131116 245__ $$aMathematical birth of early afterdepolarizations in a cardiomyocyte model 000131116 260__ $$c2023 000131116 5060_ $$aAccess copy available to the general public$$fUnrestricted 000131116 5203_ $$aEarly Afterdepolarizations (EADs) are abnormal behaviors that can lead to cardiac failure and even cardiac death. In this paper we investigate the occurrence and development of these phenomena in a reduced Luo–Rudy cardiac model. Through a comprehensive dynamical analysis, we map out the distinct patterns observed in the parametric plane, differentiating between normal beats without EADs and pathological beats with EADs. By examining the bifurcation structure of the model, we elucidate the dynamical elements associated with these patterns and their transitions. Using a fast–slow analysis, we explore the emergence and evolution of EADs in the model. Notably, our approach combines the two commonly used fast–slow approaches (1-slow–2-fast and 2-slow–1-fast), and we show how both approaches together provide a more complete understanding of this phenomenon. 000131116 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2021-122961NB-I00$$9info:eu-repo/grantAgreement/ES/DGA-FSE/E24-20R$$9info:eu-repo/grantAgreement/ES/DGA/LMP94_21$$9info:eu-repo/grantAgreement/ES/MICINN-AEI/PID2020-113052GB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-105674RB-I00$$9info:eu-repo/grantAgreement/EUR/MICINN/TED2021-130459B-I00 000131116 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000131116 590__ $$a1.9$$b2023 000131116 592__ $$a0.639$$b2023 000131116 591__ $$aBIOLOGY$$b52 / 109 = 0.477$$c2023$$dQ2$$eT2 000131116 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2023$$dQ1 000131116 591__ $$aMATHEMATICAL & COMPUTATIONAL BIOLOGY$$b37 / 66 = 0.561$$c2023$$dQ3$$eT2 000131116 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2023$$dQ2 000131116 593__ $$aStatistics and Probability$$c2023$$dQ2 000131116 593__ $$aMedicine (miscellaneous)$$c2023$$dQ2 000131116 593__ $$aModeling and Simulation$$c2023$$dQ2 000131116 593__ $$aApplied Mathematics$$c2023$$dQ2 000131116 593__ $$aImmunology and Microbiology (miscellaneous)$$c2023$$dQ2 000131116 594__ $$a7.5$$b2023 000131116 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000131116 700__ $$0(orcid)0000-0001-9868-9368$$aJover-Galtier, J.A.$$uUniversidad de Zaragoza 000131116 700__ $$0(orcid)0000-0002-7374-3222$$aMartínez, M.A.$$uUniversidad de Zaragoza 000131116 700__ $$aPérez, L. 000131116 700__ $$0(orcid)0000-0002-5701-1670$$aSerrano, S.$$uUniversidad de Zaragoza 000131116 7102_ $$12005$$2595$$aUniversidad de Zaragoza$$bDpto. Matemática Aplicada$$cÁrea Matemática Aplicada 000131116 773__ $$g366 (2023), 109088 [13 pp.]$$pMath. biosci.$$tMATHEMATICAL BIOSCIENCES$$x0025-5564 000131116 8564_ $$s5719055$$uhttps://zaguan.unizar.es/record/131116/files/texto_completo.pdf$$yVersión publicada 000131116 8564_ $$s2562243$$uhttps://zaguan.unizar.es/record/131116/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000131116 909CO $$ooai:zaguan.unizar.es:131116$$particulos$$pdriver 000131116 951__ $$a2024-11-22-12:01:07 000131116 980__ $$aARTICLE