000131116 001__ 131116
000131116 005__ 20241125101136.0
000131116 0247_ $$2doi$$a10.1016/j.mbs.2023.109088
000131116 0248_ $$2sideral$$a136706
000131116 037__ $$aART-2023-136706
000131116 041__ $$aeng
000131116 100__ $$0(orcid)0000-0002-8089-343X$$aBarrio, R.$$uUniversidad de Zaragoza
000131116 245__ $$aMathematical birth of early afterdepolarizations in a cardiomyocyte model
000131116 260__ $$c2023
000131116 5060_ $$aAccess copy available to the general public$$fUnrestricted
000131116 5203_ $$aEarly Afterdepolarizations (EADs) are abnormal behaviors that can lead to cardiac failure and even cardiac death. In this paper we investigate the occurrence and development of these phenomena in a reduced Luo–Rudy cardiac model. Through a comprehensive dynamical analysis, we map out the distinct patterns observed in the parametric plane, differentiating between normal beats without EADs and pathological beats with EADs. By examining the bifurcation structure of the model, we elucidate the dynamical elements associated with these patterns and their transitions. Using a fast–slow analysis, we explore the emergence and evolution of EADs in the model. Notably, our approach combines the two commonly used fast–slow approaches (1-slow–2-fast and 2-slow–1-fast), and we show how both approaches together provide a more complete understanding of this phenomenon.
000131116 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2021-122961NB-I00$$9info:eu-repo/grantAgreement/ES/DGA-FSE/E24-20R$$9info:eu-repo/grantAgreement/ES/DGA/LMP94_21$$9info:eu-repo/grantAgreement/ES/MICINN-AEI/PID2020-113052GB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-105674RB-I00$$9info:eu-repo/grantAgreement/EUR/MICINN/TED2021-130459B-I00
000131116 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000131116 590__ $$a1.9$$b2023
000131116 592__ $$a0.639$$b2023
000131116 591__ $$aBIOLOGY$$b52 / 109 = 0.477$$c2023$$dQ2$$eT2
000131116 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2023$$dQ1
000131116 591__ $$aMATHEMATICAL & COMPUTATIONAL BIOLOGY$$b37 / 66 = 0.561$$c2023$$dQ3$$eT2
000131116 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2023$$dQ2
000131116 593__ $$aStatistics and Probability$$c2023$$dQ2
000131116 593__ $$aMedicine (miscellaneous)$$c2023$$dQ2
000131116 593__ $$aModeling and Simulation$$c2023$$dQ2
000131116 593__ $$aApplied Mathematics$$c2023$$dQ2
000131116 593__ $$aImmunology and Microbiology (miscellaneous)$$c2023$$dQ2
000131116 594__ $$a7.5$$b2023
000131116 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000131116 700__ $$0(orcid)0000-0001-9868-9368$$aJover-Galtier, J.A.$$uUniversidad de Zaragoza
000131116 700__ $$0(orcid)0000-0002-7374-3222$$aMartínez, M.A.$$uUniversidad de Zaragoza
000131116 700__ $$aPérez, L.
000131116 700__ $$0(orcid)0000-0002-5701-1670$$aSerrano, S.$$uUniversidad de Zaragoza
000131116 7102_ $$12005$$2595$$aUniversidad de Zaragoza$$bDpto. Matemática Aplicada$$cÁrea Matemática Aplicada
000131116 773__ $$g366 (2023), 109088 [13 pp.]$$pMath. biosci.$$tMATHEMATICAL BIOSCIENCES$$x0025-5564
000131116 8564_ $$s5719055$$uhttps://zaguan.unizar.es/record/131116/files/texto_completo.pdf$$yVersión publicada
000131116 8564_ $$s2562243$$uhttps://zaguan.unizar.es/record/131116/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000131116 909CO $$ooai:zaguan.unizar.es:131116$$particulos$$pdriver
000131116 951__ $$a2024-11-22-12:01:07
000131116 980__ $$aARTICLE