Mathematical birth of early afterdepolarizations in a cardiomyocyte model

Barrio, R. (Universidad de Zaragoza) ; Jover-Galtier, J.A. (Universidad de Zaragoza) ; Martínez, M.A. (Universidad de Zaragoza) ; Pérez, L. ; Serrano, S. (Universidad de Zaragoza)

Resumen: Early Afterdepolarizations (EADs) are abnormal behaviors that can lead to cardiac failure and even cardiac death. In this paper we investigate the occurrence and development of these phenomena in a reduced Luo–Rudy cardiac model. Through a comprehensive dynamical analysis, we map out the distinct patterns observed in the parametric plane, differentiating between normal beats without EADs and pathological beats with EADs. By examining the bifurcation structure of the model, we elucidate the dynamical elements associated with these patterns and their transitions. Using a fast–slow analysis, we explore the emergence and evolution of EADs in the model. Notably, our approach combines the two commonly used fast–slow approaches (1-slow–2-fast and 2-slow–1-fast), and we show how both approaches together provide a more complete understanding of this phenomenon.

Idioma: Inglés

DOI: 10.1016/j.mbs.2023.109088

Año: 2023

Publicado en: MATHEMATICAL BIOSCIENCES 366 (2023), 109088 [13 pp.]
ISSN: 0025-5564

Factor impacto JCR: 1.9 (2023)

Categ. JCR: BIOLOGY rank: 52 / 109 = 0.477 (2023) - Q2 - T2
Categ. JCR: MATHEMATICAL & COMPUTATIONAL BIOLOGY rank: 37 / 66 = 0.561 (2023) - Q3 - T2

Factor impacto CITESCORE: 7.5 - Applied Mathematics (Q1) - Biochemistry, Genetics and Molecular Biology (all) (Q1) - Statistics and Probability (Q1) - Medicine (all) (Q1) - Immunology and Microbiology (all) (Q1) - Agricultural and Biological Sciences (all) (Q1) - Modeling and Simulation (Q1)

Factor impacto SCIMAGO: 0.639 - Agricultural and Biological Sciences (miscellaneous) (Q1) - Biochemistry, Genetics and Molecular Biology (miscellaneous) (Q2) - Statistics and Probability (Q2) - Medicine (miscellaneous) (Q2) - Modeling and Simulation (Q2) - Applied Mathematics (Q2) - Immunology and Microbiology (miscellaneous) (Q2)

Financiación: info:eu-repo/grantAgreement/ES/AEI/PID2021-122961NB-I00
Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/E24-20R
Financiación: info:eu-repo/grantAgreement/ES/DGA/LMP94_21
Financiación: info:eu-repo/grantAgreement/ES/MICINN-AEI/PID2020-113052GB-I00
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2019-105674RB-I00
Financiación: info:eu-repo/grantAgreement/EUR/MICINN/TED2021-130459B-I00

Tipo y forma: Article (Published version)

Área (Departamento): Área Matemática Aplicada (Dpto. Matemática Aplicada)