000131240 001__ 131240 000131240 005__ 20240206154530.0 000131240 0247_ $$2doi$$a10.1177/2048872615589512 000131240 0248_ $$2sideral$$a136769 000131240 037__ $$aART-2015-136769 000131240 041__ $$aeng 000131240 100__ $$aNúñez-Gil, Iván J 000131240 245__ $$aSecondary forms of Takotsubo cardiomyopathy: A whole different prognosis 000131240 260__ $$c2015 000131240 5203_ $$aBackground Takotsubo syndrome (TKS) usually mimics an acute coronary syndrome. However, several clinical forms have been reported. Our aim was to assess if different stressful triggers had prognostic influence on TKS, and to establish a working classification. Methods We performed an analysis including patients with TKS between 2003–2013 from our prospective local database and the RETAKO National Registry, fulfilling Mayo criteria. Patients were divided in two groups regarding their potential triggers: (a) none/psychic stress as ‘primary forms’ and (b) physical factors (asthma, surgery, trauma, etc.) as ‘secondary forms’. Results Finally, 328 patients were included, 90.2% women, with a mean age of 69.7 years. Patients were divided into primary TKS (n=265) and 63 secondary TKS groups. Age, gender, previous functional class and cardiovascular risk profile displayed no differences between groups before admission. However, primary-TKS patients suffered a main complaint of chest pain (89.4% vs 50.7%, p<0.0001) with frequent vegetative symptoms. Regarding treatment before admission, there were no differences either. During admission, differences were related to more intensive antithrombotic and anxiolytic drug use in the primary TKS group. Inotropic and mechanical ventilation use was higher in the secondary cohort. After discharge, a more frequent prescription of beta-blockers and statins in primary-TKS patients was seen. Secondary forms displayed more in-hospital stay and evolutive complications: death (hazard ratio (HR): 3.41; 95% confidence interval (CI): 1.14–10.16, p=0.02), combined event variable (MACE) (HR: 1.61; 95% CI: 1.01–2.6, p=0.04) and recurrences (HR: 1.85; 95% CI: 1.06–3.22, p=0.02). Conclusion Secondary TKS could present or mark worse short and long-term prognoses in terms of mortality, recurrences and readmissions. We propose a simple working nomenclature for TKS. 000131240 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000131240 592__ $$a1.322$$b2015 000131240 593__ $$aCardiology and Cardiovascular Medicine$$c2015$$dQ1 000131240 593__ $$aMedicine (miscellaneous)$$c2015$$dQ1 000131240 593__ $$aCritical Care and Intensive Care Medicine$$c2015$$dQ1 000131240 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000131240 700__ $$aAlmendro-Delia, Manuel 000131240 700__ $$aAndrés, Mireia 000131240 700__ $$aSionis, Alessandro 000131240 700__ $$aMartin, Ana 000131240 700__ $$aBastante, Teresa 000131240 700__ $$aCórdoba-Soriano, Juan G 000131240 700__ $$0(orcid)0000-0002-4236-6954$$aLinares, José A$$uUniversidad de Zaragoza 000131240 700__ $$aGonzález Sucarrats, Silvia 000131240 700__ $$aSánchez-Grande-Flecha, Alejandro 000131240 700__ $$aFabregat-Andrés, Oscar 000131240 700__ $$aPérez, Beatriz 000131240 700__ $$aEscudier-Villa, Juan M 000131240 700__ $$aMartin-Reyes, Roberto 000131240 700__ $$aPérez-Castellanos, Alberto 000131240 700__ $$aRueda Sobella, Ferrán 000131240 700__ $$aCambeiro, Cristina 000131240 700__ $$aPiqueras-Flores, Jesús 000131240 700__ $$aVidal-Perez, Rafael 000131240 700__ $$aBodí, Vicente 000131240 700__ $$aGarcía de la Villa, Bernardo 000131240 700__ $$aCorbí-Pascua, Miguel 000131240 700__ $$aBiagioni, Corina 000131240 700__ $$aMejía-Rentería, Hernán D 000131240 700__ $$aFeltes, Gisela 000131240 700__ $$aBarrabés, José 000131240 700__ $$a 000131240 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000131240 773__ $$g5, 4 (2015), 308-316$$pEur. heart j. acute cardiovasc. care$$tEUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE$$x2048-8726 000131240 8564_ $$s1067726$$uhttps://zaguan.unizar.es/record/131240/files/texto_completo.pdf$$yVersión publicada 000131240 8564_ $$s2459501$$uhttps://zaguan.unizar.es/record/131240/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000131240 909CO $$ooai:zaguan.unizar.es:131240$$particulos$$pdriver 000131240 951__ $$a2024-02-06-14:52:45 000131240 980__ $$aARTICLE