000131240 001__ 131240
000131240 005__ 20240206154530.0
000131240 0247_ $$2doi$$a10.1177/2048872615589512
000131240 0248_ $$2sideral$$a136769
000131240 037__ $$aART-2015-136769
000131240 041__ $$aeng
000131240 100__ $$aNúñez-Gil, Iván J
000131240 245__ $$aSecondary forms of Takotsubo cardiomyopathy: A whole different prognosis
000131240 260__ $$c2015
000131240 5203_ $$aBackground
Takotsubo syndrome (TKS) usually mimics an acute coronary syndrome. However, several clinical forms have been reported. Our aim was to assess if different stressful triggers had prognostic influence on TKS, and to establish a working classification.
Methods
We performed an analysis including patients with TKS between 2003–2013 from our prospective local database and the RETAKO National Registry, fulfilling Mayo criteria. Patients were divided in two groups regarding their potential triggers: (a) none/psychic stress as ‘primary forms’ and (b) physical factors (asthma, surgery, trauma, etc.) as ‘secondary forms’.
Results
Finally, 328 patients were included, 90.2% women, with a mean age of 69.7 years. Patients were divided into primary TKS (n=265) and 63 secondary TKS groups. Age, gender, previous functional class and cardiovascular risk profile displayed no differences between groups before admission. However, primary-TKS patients suffered a main complaint of chest pain (89.4% vs 50.7%, p<0.0001) with frequent vegetative symptoms. Regarding treatment before admission, there were no differences either. During admission, differences were related to more intensive antithrombotic and anxiolytic drug use in the primary TKS group. Inotropic and mechanical ventilation use was higher in the secondary cohort. After discharge, a more frequent prescription of beta-blockers and statins in primary-TKS patients was seen. Secondary forms displayed more in-hospital stay and evolutive complications: death (hazard ratio (HR): 3.41; 95% confidence interval (CI): 1.14–10.16, p=0.02), combined event variable (MACE) (HR: 1.61; 95% CI: 1.01–2.6, p=0.04) and recurrences (HR: 1.85; 95% CI: 1.06–3.22, p=0.02).
Conclusion
Secondary TKS could present or mark worse short and long-term prognoses in terms of mortality, recurrences and readmissions. We propose a simple working nomenclature for TKS.
000131240 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000131240 592__ $$a1.322$$b2015
000131240 593__ $$aCardiology and Cardiovascular Medicine$$c2015$$dQ1
000131240 593__ $$aMedicine (miscellaneous)$$c2015$$dQ1
000131240 593__ $$aCritical Care and Intensive Care Medicine$$c2015$$dQ1
000131240 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000131240 700__ $$aAlmendro-Delia, Manuel
000131240 700__ $$aAndrés, Mireia
000131240 700__ $$aSionis, Alessandro
000131240 700__ $$aMartin, Ana
000131240 700__ $$aBastante, Teresa
000131240 700__ $$aCórdoba-Soriano, Juan G
000131240 700__ $$0(orcid)0000-0002-4236-6954$$aLinares, José A$$uUniversidad de Zaragoza
000131240 700__ $$aGonzález Sucarrats, Silvia
000131240 700__ $$aSánchez-Grande-Flecha, Alejandro
000131240 700__ $$aFabregat-Andrés, Oscar
000131240 700__ $$aPérez, Beatriz
000131240 700__ $$aEscudier-Villa, Juan M
000131240 700__ $$aMartin-Reyes, Roberto
000131240 700__ $$aPérez-Castellanos, Alberto
000131240 700__ $$aRueda Sobella, Ferrán
000131240 700__ $$aCambeiro, Cristina
000131240 700__ $$aPiqueras-Flores, Jesús
000131240 700__ $$aVidal-Perez, Rafael
000131240 700__ $$aBodí, Vicente
000131240 700__ $$aGarcía de la Villa, Bernardo
000131240 700__ $$aCorbí-Pascua, Miguel
000131240 700__ $$aBiagioni, Corina
000131240 700__ $$aMejía-Rentería, Hernán D
000131240 700__ $$aFeltes, Gisela
000131240 700__ $$aBarrabés, José
000131240 700__ $$a
000131240 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000131240 773__ $$g5, 4 (2015), 308-316$$pEur. heart j. acute cardiovasc. care$$tEUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE$$x2048-8726
000131240 8564_ $$s1067726$$uhttps://zaguan.unizar.es/record/131240/files/texto_completo.pdf$$yVersión publicada
000131240 8564_ $$s2459501$$uhttps://zaguan.unizar.es/record/131240/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000131240 909CO $$ooai:zaguan.unizar.es:131240$$particulos$$pdriver
000131240 951__ $$a2024-02-06-14:52:45
000131240 980__ $$aARTICLE