Rationale and design of a multicenter, international and collaborative Coronary Artery Aneurysm Registry (CAAR)

Nombela-Franco, Luis ; Bagur, Roberto ; Bollati, Mario ; Cerrato, Enrico ; Alfonso, Emilio ; Liebetrau, Christoph ; De la Torre Hernández, José María ; Camacho, Benjamín ; Mila, Rafael ; Amat-Santos, Ignacio J. ; Alfonso, Fernando ; Rodríguez-Olivares, Ramón ; Camacho Freire, Santiago J. ; Lozano, Iñigo ; Jiménez Díaz, Víctor Alfonso ; Piraino, Davide ; Latini, Roberto Adriano ; Feltes, Gisela ; Linares, José Antonio (Universidad de Zaragoza) ; Mancone, Massimo ; Lelasi, Alfonso ; Sánchez-Grande Flecha, Alejandro ; Fernández Cisnal, Agustín ; Ugo, Fabrizio ; Jiménez Mazuecos, Jesús M. ; Omedè, Pier Luigi ; Pavani, Marco ; Villablanca, Pedro A. ; Louka, Boshra F. ; Fernández-Ortiz, Antonio ; on behalf of the CAAR Investigators

Resumen: Coronary artery aneurysm is defined as a coronary dilation that exceeds the diameter of adjacent segments or the diameter of the patient's largest normal coronary vessel by 1.5×. It is an uncommon disease that has been diagnosed with increasing frequency since the widespread appearance of coronary angiography. The published incidence varies from 1.5% to 5%, suggesting male dominance and a predilection for the right coronary artery. Although several causes have been described, atherosclerosis accounts for ≥50% of coronary aneurysms in adults. Reported complications include thrombosis and distal embolization, rupture, and vasospasm, causing ischemia, heart failure, or arrhythmias. The natural history and prognosis remain unknown, as definitive data are scarce. Controversies persist regarding the use of medical management (antithrombotic therapy) or interventional/surgical procedures. Only some case reports or small case series are available about this condition. The Coronary Artery Aneurysm Registry (CAAR; http://www.ClinicalTrials.gov NCT02563626) is a multicenter international ambispective registry that aims to provide insights on anatomic, epidemiologic, and clinical aspects of this substantially unknown entity. In addition, the registry will assess management strategies (conservative, interventional, or surgical) and their short- and long-term results in a large cohort of patients.

Idioma: Inglés

DOI: 10.1002/clc.22705

Año: 2017

Publicado en: CLINICAL CARDIOLOGY 40 (2017), 580-585
ISSN: 0160-9289

Factor impacto JCR: 2.733 (2017)

Categ. JCR: CARDIAC & CARDIOVASCULAR SYSTEMS rank: 57 / 128 = 0.445 (2017) - Q2 - T2

Factor impacto SCIMAGO: 1.42 - Medicine (miscellaneous) (Q1) - Cardiology and Cardiovascular Medicine (Q1)

Tipo y forma: Article (PostPrint)

Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)