Anxiety and risk of dementia: Systematic review and meta-analysis of prospective cohort studies

Santabárbara, J. (Universidad de Zaragoza) ; Lipnicki, D.M. ; Villagrasa, B. ; Lobo, E. (Universidad de Zaragoza) ; Lopez-Anton, R. (Universidad de Zaragoza)

Resumen: Objectives: Anxiety is postulated to be modifiable risk factor for dementia. Our primary aim was to conduct a meta-analysis of community-based cohort studies that investigated the association between anxiety and dementia. Design: We identified relevant, high-quality papers published up to January 2018 by searching PubMed and Web of Science. Prospective cohort studies reporting relative risks (RRs) for the association between anxiety and dementia, adjusted at least for age, were considered eligible. Study-specific RRs were combined using a random-effects model. Results: Six prospective cohorts (reported in 5 studies), with a total of 10, 394 participants, were included in the meta-analysis. The pooled RR of 1.29 (95% CI: 1.01–1.66) indicated a significant association between anxiety and dementia. Conclusion: Anxiety significantly increases the risk of dementia. However, further research is needed to determine the extent to which anxiety is a cause of dementia rather than a prodrome or marker.

Idioma: Inglés

DOI: 10.1016/j.maturitas.2018.10.014

Año: 2019

Publicado en: Maturitas 119 (2019), 14-20
ISSN: 0378-5122

Factor impacto JCR: 3.63 (2019)

Categ. JCR: OBSTETRICS & GYNECOLOGY rank: 12 / 82 = 0.146 (2019) - Q1 - T1
Categ. JCR: GERIATRICS & GERONTOLOGY rank: 14 / 51 = 0.275 (2019) - Q2 - T1

Factor impacto SCIMAGO: 1.189 - Obstetrics and Gynecology (Q1) - Biochemistry, Genetics and Molecular Biology (miscellaneous) (Q1)

Tipo y forma: Review (PostPrint)

Área (Departamento): Área Psicología Básica (Dpto. Psicología y Sociología)
Área (Departamento): Área Medic.Prevent.Salud Públ. (Dpto. Microb.Med.Pr.,Sal.Públ.)