Changes in T-peak-to-T-end Morphology Measured by Time-Warping Are Associated with Ischemia-Induced Ventricular Fibrillation in a Porcine Model

Gómez Fonseca, Neurys (Universidad de Zaragoza) ; Ramírez, Julia (Universidad de Zaragoza) ; Martin-Yebra, Alba (Universidad de Zaragoza) ; M. Demidova, Marina ; Platonov, Pyotr ; Martínez, Juan Pablo (Universidad de Zaragoza) ; Laguna, Pablo (Universidad de Zaragoza)

Resumen: In this work, we use a time-warping-based morphology variation index, dw , computed between the peak and the end of the T-wave, and assess its association with the occurrence of ventricular fibrillation (VF) episodes in ischemic conditions. ECG recordings from 26 pigs under- going a 40-minute coronary occlusion were analyzed. The dw series was obtained by quantifying the morphological differences between the final part of the T wave at different stages of the occlusion and a reference T wave in the control recording. During control recordings, dw remained stationary with a median value along each recording of 1.76 ms, IQR of 1.80, while during artery occlusion followed a well-marked gradual increasing trend as ischemia progressed, with median of 15.47 ms, IQR of 18.53. At the 20-to-25 min period from occlusion onset (and during 5 min prior to VF episode) d w averages in the VF group was significantly higher than in the non-VF group with median values of 40.0 (and 34.4) vs 7.8 (and 7.7) ms, with p-values of 0.002 (and 0.001), respectively. In conclusion, dynamic increases of the dw index during ischaemia progression in pigs are associated with VF occurrence.

Idioma: Inglés

DOI: 10.22489/CinC.2023.408

Año: 2023

Publicado en: Computing in Cardiology 50 (2023), [4 pp.]
ISSN: 2325-8861

Factor impacto CITESCORE: 1.1 - Computer Science (all) (Q4) - Cardiology and Cardiovascular Medicine (Q4)

Factor impacto SCIMAGO: 0.227 - Computer Science (miscellaneous) - Cardiology and Cardiovascular Medicine

Financiación: info:eu-repo/grantAgreement/ES/AEI/PID2021-128972OA-I00
Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R
Financiación: info:eu-repo/grantAgreement/ES/DGA/LMP141-21
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2019-104881RB-I00
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2019-105674RB-I00
Financiación: info:eu-repo/grantAgreement/ES/MICINN/RYC2021-031413-I
Financiación: info:eu-repo/grantAgreement/EUR/MICINN/TED2021-130459B-I00

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Teoría Señal y Comunicac. (Dpto. Ingeniería Electrón.Com.)