000131540 001__ 131540
000131540 005__ 20240212142201.0
000131540 0247_ $$2doi$$a10.1016/j.jmbbm.2020.104070
000131540 0248_ $$2sideral$$a120469
000131540 037__ $$aART-2021-120469
000131540 041__ $$aeng
000131540 100__ $$aDíaz, C.
000131540 245__ $$aUnraveling the multilayer mechanical response of aorta using layer-specific residual stresses and experimental properties
000131540 260__ $$c2021
000131540 5060_ $$aAccess copy available to the general public$$fUnrestricted
000131540 5203_ $$aTo test the capability of the multilayer model, we used previously published layer-specific experimental data relating to the axial pre-stretch, the opening angle, the fiber distribution obtained by polarized light microscopy measurements, and the uniaxial and biaxial response of the porcine descending and abdominal aorta. We fitted the mechanical behavior of each arterial layer using Gasser, Holzapfel and Ogden strain energy function using the dispersion parameter ¿ as phenomenological parameter obtained during the fitting procedure or computed from the experimental fiber distribution. A multilayer finite element model of the whole aorta with the dimensions of the circumferential and longitudinal strips were then built using layer-specific material parameters previously fitted. This model was used to capture the whole aorta response under uniaxial and biaxial stress states and to reproduce the response of the whole aorta to internal pressure. Our results show that a model based on a multilayer structure without residual stresses is unable to render the uniaxial and biaxial mechanical response of the aorta (R2=0.6954 and R2=0.8582 for descending thoracic aorta (DTA) and infrarenal abdominal aorta (IAA), respectively). Only an appropriate multilayer model that includes layer-specific residual stresses can reproduce the response of the whole aorta (R2=0.9787 and R2=0.9636 for DTA and IAA respectively). In addition, a multilayer model without residual stresses produces the same stress distribution as a monolayer model without residual stresses where the maximal value of circumferential and longitudinal stresses appears at the inner radius of the intima. Finally, if layer-specific residual stresses are not available, there is less error the stress distribution using a monolayer model with residual stresses that a multilayer model without residual stresses.
000131540 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/T24-20R$$9info:eu-repo/grantAgreement/ES/DGA/LMP121-18$$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-107517RB-I00$$9info:eu-repo/grantAgreement/ES/MINECO/DPI2016-76630-C2-1-R
000131540 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000131540 590__ $$a4.042$$b2021
000131540 591__ $$aENGINEERING, BIOMEDICAL$$b48 / 98 = 0.49$$c2021$$dQ2$$eT2
000131540 591__ $$aMATERIALS SCIENCE, BIOMATERIALS$$b27 / 45 = 0.6$$c2021$$dQ3$$eT2
000131540 592__ $$a0.746$$b2021
000131540 593__ $$aBiomedical Engineering$$c2021$$dQ2
000131540 593__ $$aBiomaterials$$c2021$$dQ2
000131540 594__ $$a6.6$$b2021
000131540 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000131540 700__ $$0(orcid)0000-0002-4268-7424$$aPeña, J. A.$$uUniversidad de Zaragoza
000131540 700__ $$0(orcid)0000-0002-8375-0354$$aMartínez, M. A.$$uUniversidad de Zaragoza
000131540 700__ $$0(orcid)0000-0002-0664-5024$$aPeña, E.$$uUniversidad de Zaragoza
000131540 7102_ $$15002$$2305$$aUniversidad de Zaragoza$$bDpto. Ingeniería Diseño Fabri.$$cÁrea Expresión Gráfica en Ing.
000131540 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000131540 773__ $$g113 (2021), 104070 [15 pp.]$$pJ. mech. behav. boomed. mater.$$tJournal of the Mechanical Behavior of Biomedical Materials$$x1751-6161
000131540 8564_ $$s3454916$$uhttps://zaguan.unizar.es/record/131540/files/texto_completo.pdf$$yPostprint
000131540 8564_ $$s1971037$$uhttps://zaguan.unizar.es/record/131540/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000131540 909CO $$ooai:zaguan.unizar.es:131540$$particulos$$pdriver
000131540 951__ $$a2024-02-12-13:54:48
000131540 980__ $$aARTICLE