000131598 001__ 131598
000131598 005__ 20250210083428.0
000131598 0247_ $$2doi$$a10.1039/d3nj03186a
000131598 0248_ $$2sideral$$a136921
000131598 037__ $$aART-2023-136921
000131598 041__ $$aeng
000131598 100__ $$aD’Arcy, Kenneth
000131598 245__ $$aUnusual tellurium(iv) mediated cyclisation diols into dihydroxazoles with potential anticancer activity
000131598 260__ $$c2023
000131598 5203_ $$aThe role of tellurium in medicinal chemistry has recently grown in importance due to the discovery of the anticancer properties of SAS and AS-101, two inorganic compounds based on Te(IV). Here we describe an unprecedented isolation of a series of tetramethyl-dihydroxazole tellurium hexachloride salts whose structure has been indentified and characterised with several techniques including X-ray crystallography. The novelty resides on the role of tellurium that mediate the cyclisation of 1,1,2,2-tetramethylethylene into duhydroxazole in the presence of nitriles. Reaction mechanism, physiological stability and preliminary cytotoxicity results are discussed.
000131598 536__ $$9info:eu-repo/grantAgreement/ES/MCIU-AEI-FEDER/PID2021-122406NB-I00$$9info:eu-repo/grantAgreement/ES/DGA/E42-23R
000131598 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000131598 590__ $$a2.7$$b2023
000131598 592__ $$a0.521$$b2023
000131598 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b111 / 231 = 0.481$$c2023$$dQ2$$eT2
000131598 593__ $$aChemistry (miscellaneous)$$c2023$$dQ2
000131598 593__ $$aMaterials Chemistry$$c2023$$dQ2
000131598 593__ $$aCatalysis$$c2023$$dQ3
000131598 594__ $$a5.3$$b2023
000131598 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000131598 700__ $$aSchäfer, Tim
000131598 700__ $$aDe Franco, Michele
000131598 700__ $$aRicco, Raffaele
000131598 700__ $$aGandin, Valentina
000131598 700__ $$0(orcid)0000-0002-8220-6031$$aSanz Miguel, Pablo J.$$uUniversidad de Zaragoza
000131598 700__ $$aMontagner, Diego
000131598 7102_ $$12010$$2760$$aUniversidad de Zaragoza$$bDpto. Química Inorgánica$$cÁrea Química Inorgánica
000131598 773__ $$g47, 39 (2023), 18485-18491$$pNew j. chem.$$tNEW JOURNAL OF CHEMISTRY$$x1144-0546
000131598 8564_ $$s552689$$uhttps://zaguan.unizar.es/record/131598/files/texto_completo.pdf$$yPostprint
000131598 8564_ $$s1539998$$uhttps://zaguan.unizar.es/record/131598/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000131598 909CO $$ooai:zaguan.unizar.es:131598$$particulos$$pdriver
000131598 951__ $$a2025-02-10-08:31:25
000131598 980__ $$aARTICLE