Unusual tellurium(iv) mediated cyclisation diols into dihydroxazoles with potential anticancer activity

D’Arcy, Kenneth ; Schäfer, Tim ; De Franco, Michele ; Ricco, Raffaele ; Gandin, Valentina ; Sanz Miguel, Pablo J. (Universidad de Zaragoza) ; Montagner, Diego

Resumen: The role of tellurium in medicinal chemistry has recently grown in importance due to the discovery of the anticancer properties of SAS and AS-101, two inorganic compounds based on Te(IV). Here we describe an unprecedented isolation of a series of tetramethyl-dihydroxazole tellurium hexachloride salts whose structure has been indentified and characterised with several techniques including X-ray crystallography. The novelty resides on the role of tellurium that mediate the cyclisation of 1,1,2,2-tetramethylethylene into duhydroxazole in the presence of nitriles. Reaction mechanism, physiological stability and preliminary cytotoxicity results are discussed.

Idioma: Inglés

DOI: 10.1039/d3nj03186a

Año: 2023

Publicado en: NEW JOURNAL OF CHEMISTRY 47, 39 (2023), 18485-18491
ISSN: 1144-0546

Factor impacto JCR: 2.7 (2023)

Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 111 / 231 = 0.481 (2023) - Q2 - T2

Factor impacto CITESCORE: 5.3 - Chemistry (all) (Q2) - Materials Chemistry (Q2) - Catalysis (Q3)

Factor impacto SCIMAGO: 0.521 - Chemistry (miscellaneous) (Q2) - Materials Chemistry (Q2) - Catalysis (Q3)

Financiación: info:eu-repo/grantAgreement/ES/DGA/E42-23R
Financiación: info:eu-repo/grantAgreement/ES/MCIU-AEI-FEDER/PID2021-122406NB-I00

Tipo y forma: Artículo (PostPrint)

Área (Departamento): Área Química Inorgánica (Dpto. Química Inorgánica)