RTS,S/AS02A Malaria Vaccine-Induced IgG Responses Equally Recognize Native-Like Fucosylated and Nonfucosylated <i>Plasmodium falciparum</i> Circumsporozoite Proteins

Jairoce, Chenjerai ; Macià, Dídac ; Torres-Yaguana, Jorge P ; Mayer, Leonie ; Vidal, Marta ; Santano, Rebeca ; Hurtado-Guerrero, Ramón ; Reiter, Karine ; Narum, David L ; Lopez-Gutierrez, Borja ; Hamerly, Timothy ; Sacarlal, Jahit ; Aguilar, Ruth ; Dinglasan, Rhoel R ; Moncunill, Gemma ; Izquierdo, Luis ; Dobaño, Carlota

Resumen: The RTS,S/AS02A malaria vaccine is based on the Plasmodium falciparum circumsporozoite protein (PfCSP), which is O-fucosylated on the sporozoite surface. We determined whether RTS,S/AS02A-induced immunoglobulin G (IgG) antibodies recognize vaccine-like nonfucosylated PfCSP better than native-like fucosylated PfCSP. Similar to previous vaccine trials, RTS,S/AS02A vaccination induced high anti-PfCSP IgG levels associated with malaria protection. IgG recognition of nonfucosylated and fucosylated PfCSP was equivalent, suggesting that PfCSP fucosylation does not affect antibody recognition.

Idioma: Inglés

DOI: 10.1093/infdis/jiad471

Año: 2024

Publicado en: JOURNAL OF INFECTIOUS DISEASES 229, 3 (2024), 795–799
ISSN: 0022-1899

Factor impacto SCIMAGO: 2.387 - Infectious Diseases (Q1) - Immunology and Allergy (Q1)

Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2019-110810RB-I00/AEI/10.13039/501100011033
Financiación: info:eu-repo/grantAgreement/ES/MICINN/RYC2020-029886-I/AEI/10.13039/501100011033

Tipo y forma: Article (Published version)