000131728 001__ 131728
000131728 005__ 20240731103412.0
000131728 0247_ $$2doi$$a10.1002/adsc.202300563
000131728 0248_ $$2sideral$$a137051
000131728 037__ $$aART-2023-137051
000131728 041__ $$aeng
000131728 100__ $$0(orcid)0000-0001-6832-8983$$aMarqués-López, Eugenia$$uUniversidad de Zaragoza
000131728 245__ $$aAsymmetric organocatalyzed phospha-michael addition for the direct synthesis of biologically active chromenylphosphonates
000131728 260__ $$c2023
000131728 5060_ $$aAccess copy available to the general public$$fUnrestricted
000131728 5203_ $$aThe potential of phosphites as nucleophiles for the asymmetric synthesis of chiral chromene derivatives has been overlooked in the literature. Herein, we report a promising approach via asymmetric organocatalyzed phospha‐Michael addition to iminochromenes, using a bifunctional squaramide, which gives access to chromenylphosphonates, an interesting family of bioactive compounds. Our optimized protocol provides very good reactivity, affording yields of up to 95% and with chiral products exhibiting an enantiomeric excess of up to 98%.
000131728 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2019-104379RB-C21$$9info:eu-repo/grantAgreement/ES/AEI/PID2020-117455GB-I00$$9info:eu-repo/grantAgreement/ES/DGA/E07-23R
000131728 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000131728 590__ $$a4.4$$b2023
000131728 592__ $$a1.02$$b2023
000131728 591__ $$aCHEMISTRY, ORGANIC$$b8 / 58 = 0.138$$c2023$$dQ1$$eT1
000131728 593__ $$aOrganic Chemistry$$c2023$$dQ1
000131728 591__ $$aCHEMISTRY, APPLIED$$b19 / 74 = 0.257$$c2023$$dQ2$$eT1
000131728 593__ $$aCatalysis$$c2023$$dQ2
000131728 594__ $$a9.4$$b2023
000131728 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000131728 700__ $$aGimeno Sonsona, Isaac
000131728 700__ $$aGarcés-Marín, Miryam
000131728 700__ $$0(orcid)0000-0003-0553-0695$$aGimeno, M. Concepción
000131728 700__ $$0(orcid)0000-0002-5244-9569$$aPérez Herrera, Raquel
000131728 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000131728 773__ $$g365, 19 (2023), 3234-3240$$pAdv. synth. catal.$$tAdvanced Synthesis and Catalysis$$x1615-4150
000131728 8564_ $$s5422445$$uhttps://zaguan.unizar.es/record/131728/files/texto_completo.pdf$$yVersión publicada
000131728 8564_ $$s2976073$$uhttps://zaguan.unizar.es/record/131728/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000131728 909CO $$ooai:zaguan.unizar.es:131728$$particulos$$pdriver
000131728 951__ $$a2024-07-31-10:04:32
000131728 980__ $$aARTICLE