Electrophysiological findings in long-term type 1 diabetes patients without diabetic retinopathy using different ERG recording systems

Arias Álvarez, Marta ; Tomas-Grasa, Cristina ; Sopeña-Pinilla, María ; Orduna-Hospital, Elvira (Universidad de Zaragoza) ; Fernández-Espinosa, Guisela (Universidad de Zaragoza) ; Bielsa Alonso, Sofia ; Acha-Pérez, Javier ; Rodriguez-Mena, Diego (Universidad de Zaragoza) ; Pinilla, Isabel (Universidad de Zaragoza)

Resumen: To assess full-field electroretinogram findings in long-term type 1 diabetes patients without diabetic retinopathy. Prospective study including 46 eyes of 23 patients with type 1 diabetes and 46 age-matched healthy eyes evaluated by the RETI-port/scan21 and the portable system RETeval following ISCEV guidelines. The average duration of diabetes was 28.88 ± 8.04 years. In scotopic conditions, using the RETI-port/scan21, diabetic patients showed an increase in b-wave implicit time (IT) (p = 0.017) with the lowest stimuli; a diminished b-wave amplitude (p = 0.005) in the mixed response, an increased IT (p = 0.004) with the high-intensity stimuli and an OP2 increased IT (p = 0.008) and decreased amplitude (p = 0.002). Under photopic conditions, b-wave amplitude was lower (p < 0.001) and 30-Hz flicker response was diminished (p = 0.021). Using the RETeval, in scotopic conditions, diabetic patients showed a reduction in the rod b-wave amplitude (p = 0.009), an increase in a-wave IT with the 280 Td.s stimulus (p = 0.005). OP2 had an increased IT and diminished amplitude (p = 0.003 and p = 0.002 respectively). 16 Td.s flicker showed an increased IT (p = 0.008) and diminished amplitude (p = 0.048). Despite variations in values between both systems, nearly all results displayed positive correlations. Long-term type 1 diabetes patients without diabetic retinopathy exhibit alterations in scotopic conditions, as evidenced by both conventional and portable electroretinogram devices. These findings suggest a modified retinal function, particularly in rod-driven pathways, even in the absence of vascular signs.

Idioma: Inglés

DOI: 10.1038/s41598-024-54099-5

Año: 2024

Publicado en: Scientific reports (Nature Publishing Group) 14, 3520 (2024), 1-13
ISSN: 2045-2322

Factor impacto JCR: 3.9 (2024)

Categ. JCR: MULTIDISCIPLINARY SCIENCES rank: 25 / 135 = 0.185 (2024) - Q1 - T1

Factor impacto SCIMAGO: 0.874 - Multidisciplinary (Q1)

Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI20-00740

Tipo y forma: Article (Published version)

Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Área Oftalmología (Dpto. Cirugía)
Área (Departamento): Área Óptica (Dpto. Física Aplicada)