Complex liquid crystal emulsions for biosensing

Concellón, Alberto ; Fong, Darryl ; Swager, Timothy M.

Resumen: Herein we describe a highly responsive optical biosensor based on dynamic complex liquid crystal (LC) emulsions. These emulsions are simple to prepare and consist of immiscible chiral nematic liquid crystals (N*) and fluorocarbon oils. In this work, we exploit the N* selective reflection to build a new sensing paradigm. Our detection strategy is based on changes in the LC/water interfacial activity of boronic acid polymeric surfactants caused by reversible interactions with IgG antibodies at the LC interface. Such biomolecular recognition events can vary the pitch length of the N* organization due to the presence of binaphthyl units in the polymeric structure, which are known to be powerful chiral dopants. We demonstrate that these interface-triggered reflection changes can be used as an effective optical read-out for the detection of the foodborne pathogen Salmonella.

Idioma: Inglés

DOI: 10.1021/jacs.1c04115

Año: 2021

Publicado en: Journal of the American Chemical Society 143, 24 (2021), 9177-9182
ISSN: 0002-7863

Factor impacto JCR: 16.383 (2021)

Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 16 / 179 = 0.089 (2021) - Q1 - T1

Factor impacto CITESCORE: 25.2 - Chemical Engineering (Q1) - Biochemistry, Genetics and Molecular Biology (Q1)

Factor impacto SCIMAGO: 5.728 - Biochemistry (Q1) - Colloid and Surface Chemistry (Q1) - Catalysis (Q1)

Tipo y forma: Artículo (PostPrint)